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1.
Braz. j. med. biol. res ; 53(8): e9950, 2020. graf
Artículo en Inglés | LILACS, ColecionaSUS | ID: biblio-1132542

RESUMEN

Pathophysiological mechanisms involved in orofacial pain and their relationship with emotional disorders have emerged as an important research area for multidisciplinary studies. In particular, temporomandibular disorders (TMD) have been evaluated clinically from both physiological and psychological perspectives. We hypothesized that an altered neuronal activity occurs in the amygdala and the dorsal raphe nucleus (DR), encephalic regions involved in the modulation of painful and emotional information. Adult male Wistar rats were used in an experimental complete Freund's adjuvant (CFA)-induced temporomandibular joint (TMJ) inflammation model. CFA was applied for 1 or 10 days, and the animals were euthanized for brain samples dissection for FosB/ΔFosB and parvalbumin (PV) immunostaining. Our results were consistent in showing that the amygdala and DR were activated in the persistent inflammatory phase (10 days) and that the expression of PV+ interneurons in the amygdala was decreased. In contrast, in the DR, the expression of PV+ interneurons was increased in persistent states of CFA-induced TMJ inflammation. Moreover, at 10 days of inflammation, there was an increased co-localization of PV+ and FosB/ΔFosB+ neurons in the basolateral and central nucleus of the amygdala. Different nuclei of the amygdala, as well as portions of the DR, were activated in the persistent phase (10 days) of TMJ inflammation. In conclusion, altered activity of the amygdala and DR was detected during persistent inflammatory nociception in the temporomandibular joint. These regions may be essential for both sensory and affective dimensions of orofacial pain.


Asunto(s)
Animales , Masculino , Ratas , Parvalbúminas/metabolismo , Articulación Temporomandibular/fisiología , Núcleo Dorsal del Rafe/metabolismo , Amígdala del Cerebelo/metabolismo , Ratas Wistar , Ratas Sprague-Dawley , Inflamación , Neuronas
2.
Mem. Inst. Oswaldo Cruz ; 96(4): 483-496, May 2001. ilus, mapas, tab
Artículo en Inglés | LILACS | ID: lil-285546

RESUMEN

During studies of Simuliidae at a suspected new focus of human onchocerciasis in central Brazil a new species of Simulium was found. Full descriptions of the adults and pupae of this species, S. cuasiexiguum, are described here, its affinities to closely related species in the subgenus Notolepria are discussed and its distribution in Brazil recorded


Asunto(s)
Animales , Masculino , Femenino , Insectos Vectores/clasificación , Oncocercosis/transmisión , Simuliidae/clasificación , Insectos Vectores/anatomía & histología , Simuliidae/anatomía & histología
3.
Mem. Inst. Oswaldo Cruz ; 88(1): 39-48, jan.-mar. 1993. tab, ilus
Artículo en Inglés | LILACS | ID: lil-117649

RESUMEN

Four cytotypes of Simulium exiguum occur in Ecuador, where this morphospecies is the primary vector of onchocerciasis. In this paper, we give the first full description of the banding pattern of the larval polytene chromosomes of the Quevedo cytotypes differ from the chromosomal standard sequence (of the Cayapa cytotype) by the fixed inversions IIL-5 and IIL-6. The Quevedo cytotype additionally differs from the standard and Bucay cytotypes by processing a differentiated X chromosome, wich is indicated by the inversion IIS-A. As the degree of reproductive isolation between the Bucay and Quevedo cytotypes has not yet been estabilished, they must be regarded as intraspecific variants of the same species. In fact, isoenzyme characterizations showed that the Bucay and Quevedo cytotypes are differentiated only to the extent expected of incipient species or geographical populations. Moreover, the sibiling species status previously given to the Bucay cytotype needs be reassessed, there being inadequate analysis from areas in Ecuador where Bucay occurs in sympatry with the standard Cayapa cytotype. No isoenzyme electromorphs were discovered that identified all or mostadult females of any one (cytotype-pure) collection


Asunto(s)
Animales , Vectores de Enfermedades , Isoenzimas/análisis , Simuliidae/análisis , Ecuador , Oncocercosis/transmisión , Simuliidae/parasitología
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