Chemical and pharmacological progress on a Tibetan folk medicine formula Bawei Chenxiang Powder / 中国中药杂志

Bawei Chenxiang Powder is a traditional Tibetan folk medicine formula, consisting of resinous wood of Aquilaria sinensis, kernel of Myristica fragrans, fruit of Choerospondias axillaris, travertine, resin of Boswellia carterii or B. bhaw-dajiana, stem of Aucklandia lappa, fruit of Terminalia chebula(roasted), and flower of Gossampinus malabarica. It has the function of clearing heart heat, nourishing heart, tranquilizing mind, and inducing resuscitation, which has been used for the treatment of coronary heart disease and angina pectoris. Modern research shows that the medicine materials of this formula mainly contain terpenoids like sesquiterpenes and triterpenes and polyphenols like flavonoids, lignans, and tannins, displaying some pharmacological activities such as anti-myocardial ischemia, anti-cerebral ischemia, and spatial learning and memory promotion. This review summaries the traditional uses, chemical constituents, and pharmacological activities research progress, hopefully to provide a reference for clarification of its pharmacological active ingredients.

Investigation on Signal Acquisition and Data Processing of A Fourier Transform Microwave Spectrometer / 分析化学

As one of the most important laboratory tools for the research of quantum chemistry and astrochemistry, a microwave spectrometer can make accurate measurement of molecular spectra arising from rotational transitions. Fourier transform microwave (FTMW) spectrometers, in many cases, require down-conversion mixing plans by using mixers to bring the molecular signal down for A/D sampling, and multiple signal averaging to improve the signal/noise ratio as well. Two detection schemes, homodyne and heterodyne detection modes,were proposed in this project along with two data processing plans, averaging in the time domain and averaging in the frequency domain,to develop efficient,sensitive and accurate detection solutions for molecular rotational spectroscopy. With 0. 5% OCS gas in argon as standard sample, verification experiment was conducted with frequency difference between LO and cavity resonance at 200 MHz and 0.4 MHz. The experimental results indicate that, the heterodyne detection method can provide better sensitivity than the homodyne scheme, but with increased cost for more devices, while the time-domain averaging can obtain much better signal-to-noise ratio than frequency-domain averaging,but with stronger data processing capacity and more time required.

A new diterpenoid from Fritillaria anhuiensis / 药学学报

The aim of this study was to look for the chemical constituents of the bulbs of Fritillaria anhuiensis S.C.Chen et S.E.Yin. The bulbs of Fritillaria anhuiensis were extracted with 95% EtOH at reflux. Isolation and purification were performed by silica gel column chromatography. Structures of pure compounds were established on the basis of spectral analysis. Three compounds were obtained and identified as 12,15-epoxy-8(17),13-labdadien-19-ol (1), ent-3β-acetoxy-kauran-16β,17-diol (2), ent-kaurane-3β,16β,17-triol (3). Compound 1 is a new labdane-type diterpenoid. Compounds 2 and 3 were obtained from Fritillaria anhuiensis for the first time.

A new diterpenoid from Fritillaria anhuiensis / 药学学报

The aim of this study was to look for the chemical constituents of the bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin. The bulbs of Fritillaria anhuiensis were extracted with 95% EtOH at reflux. Isolation and purification were performed by silica gel column chromatography. Structures of pure compounds were established on the basis of spectral analysis. Three compounds were obtained and identified as 12,15-epoxy-8(17), 13-labdadien-19-ol (1), ent-3beta-acetoxy-kauran-16beta, 17-diol (2), ent-kaurane-3beta, 16beta, 17-triol (3). Compound 1 is a new labdane-type diterpenoid. Compounds 2 and 3 were obtained from Fritillaria anhuiensis for the first time.

Effect of benzene on sperm DNA / 中华男科学杂志

<p><b>OBJECTIVE</b>To assess the effect of benzene on sperm DNA.</p><p><b>METHODS</b>Twenty-seven workers exposed to benzene for over two years were included in the experiment group and 35 unexposed ones were chosen as controls. Damage by benzene on sperm DNA was detected by modified single cell gel electrophoresis (SCGE).</p><p><b>RESULTS</b>The benzene concentration in the air of the workplace of the exposed workers was (86.49 +/- 2.83) mg/m3, twice that of the national maximum allowance (40 mg/cm3). Urinary, trans-muconic acid in the exposed group was (1.40 +/- 0.62) mg/L (n = 27), significantly higher than that of the controls [(0.82) +/- 0.16) mg/L, n = 35]. After SCGE, the percentage of head DNA in the exposed group [(70.18% +/- 7.36%, n = 13 ] was significantly lower than that of the controls (90.62% +/- 2.94%, n = 16), P < 0.001.</p><p><b>CONCLUSION</b>Higher concentration of benzene could cause damage to the sperm DNA of the workers exposed to it.</p>

Detection of numerical aberrations of chromosomes 7 and 8 in sperms of workers exposed to benzene series by two-color fluorescence in situ hybridization / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To investigate the frequency of numerical aberrations for chromosomes 7 and 8 in the sperms of workers exposed to benzene series.</p><p><b>METHODS</b>Numerical aberrations in the sperms of workers were detected by two-color fluorescence in situ hybridization with biotin labeled chromosome 7 probe (D7Z1) and digoxingenin labeled chromosome 8 probe (D8Z1).</p><p><b>RESULTS</b>The time-weight average air concentration (TWA) of benzene in the workshop was 42.29 mg/m(3), which was significantly higher than that of the national maximum allowable concentration [6 mg/m(3)]. The concentration of urinary trans,trans-muconic acid(ttMA) in the exposed group was also higher than that of the control group. In all, 155721 sperm nuclei from 15 workers in the exposed group and 123771 sperm nuclei from 12 individuals in the control group were examined. The results showed that the frequency of diploidy sperms and the frequencies of disomic sperm for chromosomes 7 and 8 in the exposed group (0.129%, 0.170%, 0.078%) were significantly higher than those of the control group (0.055%, 0.053%, 0.033%), respectively. The frequencies of nullisomic sperm for chromosomes 7 and 8 in the exposed group (0.165%, 0.088%) were also significantly increased, compared with those of the control group (0.056%, 0.029%). A statistically significant difference in the frequency of overall numerical chromosome aberrations was seen between the exposed group (0.745%) and the control group (0.289%).</p><p><b>CONCLUSION</b>The results suggested that higher concentration of benzene may induce higher frequencies of numerical aberrations in the sperms of workers exposed to benzene series.</p>

Freezing effect on sperm DNA / 中华男科学杂志

<p><b>OBJECTIVES</b>To assess the effect of freezing on the sperm DNA.</p><p><b>METHODS</b>To assess the sperm DNA preserved at -80 degrees C by using the single cell gel electrophoresis (SCGE).</p><p><b>RESULTS</b>There was no statistical difference on the time factor by analysis of variance (ANOVA).</p><p><b>CONCLUSIONS</b>Integrity of sperm DNA could not be devastated in frozen states.</p>

Application of combination transfer pump to continuous blood purification / 医疗卫生装备

Objective To evaluate the effect of combination transfer pump and single blood pump to 32 cases of renal failure patient who need blood purification therapy.Methods The combination transfer pump and single blood pump were used.According to the clinical requirement,the parameters of transfer pump were set such as therapy time,replacement liquid flow rate,dialysate flow rate,temperature of warmer and filtrate flow rate,etc.Results 32 patients with varying degrees of illness have been alleviated.Patients' acute left heart failure,water and electrolyte turbulences,acid intoxication and azotemia caused by liquid retention were corrected,which ensured a role for further treatment.Conclusion It is the functions of adjustable time and transfusion volume that are used in the combination transfer pump,the task of which is accomplished by several transfer pumps together.This method is easy to implement and can meet the clinical requirement largely without special CBP instrument.