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Acta cir. bras ; 29(supl.2): 34-37, 2014. graf
Artículo en Inglés | LILACS | ID: lil-721385

RESUMEN

PURPOSE: To investigate the blood vessels' concentration in TRAM flap's rat model, in the presence of pentoxifylline. METHODS: 32 male, Wistar-EPM rats were divided into two groups. Control group (C): 0.5 ml of saline, intraperitoneally, once a day, for seven days before flap elevation; PTX group (P): pentoxifylline (20mg/kg/day), intraperitoneally, for seven days before flap elevation. After that, they were submitted to a caudal unipedicle TRAM flap. On the fifth postoperative day, percentages of flap necrosis were determined via the "paper template" method and Tram flap's zone IV skin biopsies were taken for histological analysis. RESULTS: the mean percentage of flap necrosis in group C was 58.7 % and in group P, 31.1 (Wilcoxon test; p = 0.003). Mean capillary vessels number in zone IV's skin in C group was 33.4 and in P group was 71.9 (p=0.008). CONCLUSIONS: Pentoxifylline was effective reducing the necrosis in the caudal unipedicle TRAM flap in the rat as well as increasing the number of capillaries in an ischemic zone (zone IV). .


Asunto(s)
Animales , Masculino , Capilares/efectos de los fármacos , Pentoxifilina/farmacología , Inhibidores de Agregación Plaquetaria/farmacología , Recto del Abdomen/efectos de los fármacos , Colgajos Quirúrgicos/irrigación sanguínea , Supervivencia Tisular/efectos de los fármacos , Biopsia , Capilares/patología , Modelos Animales , Necrosis , Distribución Aleatoria , Ratas Wistar , Reproducibilidad de los Resultados , Recto del Abdomen/irrigación sanguínea , Recto del Abdomen/patología , Piel/irrigación sanguínea , Piel/efectos de los fármacos , Piel/patología , Colgajos Quirúrgicos/patología
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