RESUMEN
Nicotinic acetylcholine receptors (nAChRs) exist as a diverse family of subtypes composed of different subunit combinations. They play many important physiological roles, and have been implicated in nicotine dependence and in a variety of neuropsychiatric conditions. Here I review the cholinergic hypotheses of Alzheimers and Parkinsons diseases. I provide an overview of evidence for changes in numbers of nAChR¬like binding and immunoreactive sites in both Parkinsons and Alzheimer s diseases, concerning apparent neuroprotective effects of nicotinic ligands in animal or cell culture models of those neurodegenerative disorders, and regarding therapeutic promise of nicotine and its analogs. A perspective will be presented about factors that warrant consideration in understanding possible etiopathological roles of nAChR in Alzheimers and Parkinsons diseases and in prospective nicotinic pharmacotherapy.