RESUMEN
Siddha system granting preventive, curative and rejuvenating healthcare. According to Siddha system three humours- Vatham, Pitham and Kapham- mediate the body’s physiological function. Derangements of trihumour lead to diseases. Vatha diseases are the most common diseases presenting in Siddha hospitals nowadays. In Siddha system the primary goal of the treatment is to restore the balance of trihumours. The first and foremost treatment for Vatha disease is Bhedhi (purgation). The quote ‘BhedhiyaalVathamthaalum’ indicates purgation therapy will reduce Vatham. For this study the purgative drug Agasthiyarkuzhambu is used. Aim and Objective: To make a validation of purgation therapy to alleviate Vathaim balance. To describe purgation therapy in alleviate Vathaim balance by giving Agasthiyarkuzhambu to outpatient and inpatient Department, Govt. Siddha Medical College, Palayamkottai. To observe the increased Vatha symptoms and Neikuri changes before and after treatment. Materials and methods: ANon randomized clinical trial was done with 40 patients, data were collected by interviewing with structured questionnaire about increased Vatha symptoms and samples of urine were collected to the analysis. The data will be analysed using SPSS. Results: Out of 40 patients, based on relief of Vatha symptoms 45% of cases reported good relief and 13% of cases reported better relief from their symptoms. In Neikuri before treatment 40% of cases had typical Vathaneikuri (fast, irregular, Aravu pol) and after treatment the Neikuri pattern changed to Pithavatham, Pitham and Kapham and only 10% of cases had Vathaneikuri. Neikuri and Vatha symptoms are better parameter for assessing alleviated Vatha imbalance in this study.
RESUMEN
AIM@#Considering the importance of diet in the prevention of cellular damage caused by reactive oxygen species which has been implicated for several diseases, this present study was undertaken to evaluate the in vitro and in vivo antioxidant potential of the ethanolic extract of the fruiting bodies of Ganoderma lucidum on 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in Sprague Dawley rats.@*METHODS@#Ganoderma lucidum extract was tested for in vitro antioxidant and radical scavenging assays, such as (ABTS(+)) radical cation decolorization assay, DPPH radical scavenging, hydroxyl radical, and superoxide radical scavenging assays. The in vivo antioxidant potentials were analyzed by SOD, CAT, and GPx in plasma, mammary, and liver tissues.@*RESULTS@#In all the in vitro antioxidant and radical scavenging assays the extract exhibited good scavenging activity. In vivo enzymatic antioxidant levels, such as SOD, CAT, and GPx were decreased in DMBA-induced animals. Moreover, pretreatment with G. lucidum (500 mg · kg(-1) bw) to DMBA-induced animals significantly (P < 0.05) increased the levels of SOD, CAT, and GPx in plasma, mammary, and liver tissues compared to DMBA induced animals.@*CONCLUSIONS@#From these findings, it is suggested that G. lucidum extract could be considered as a potential source of natural antioxidants and can be used as an effective chemopreventive agent against mammary cancer.