RESUMEN
The key messages of these guidel ines on chronic kidney disease are: Chronic kidney disease (CKD) is a public health problem due to its wide distribution, high rate of complications and cost. CKD is a common condition, its prevalence being about 10 percent, and is treatable if it is detected on time. A patient with CKD has a higher risk of cardiovascular mortality than of progression of its underlying renal disease. A new definition of CKD, based on estimated Glomerular Filtration Rate (eGFR) and kidney damage, facilitates its detection and management. CKD is detected with three simple tests: 1) Blood pressure measurement, 2) Detection of proteinuria or albuminuria in an isolated urine sample, and 3) Estimation of renal function (eGFR), based on serum creatinine, age, gender and race. The CKD risk groups are individuáis with diabetes, hypertension and a family history of renal disease. The most cost-effective measures are to detect and treat diabetic and hypertensive patients in the community. Therapy must emphasize the maximal reduction of cardiovascular risk. The complications of CKD such as anemia and renal osteodystrophy can be identified and treated on time. Most patients with chronic kidney disease are detected in the community, therefore their initial care must be organized at the level of primary care, along with programs for hypertension and diabetes.
Asunto(s)
Humanos , Fallo Renal Crónico/diagnóstico , Fallo Renal Crónico/terapia , Albuminuria/diagnóstico , Albuminuria/terapia , Chile , Complicaciones de la Diabetes/diagnóstico , Complicaciones de la Diabetes/terapia , Hematuria/diagnóstico , Hematuria/terapia , Hipertensión/complicaciones , Fallo Renal Crónico/complicaciones , Pruebas de Función Renal , Proteinuria/diagnóstico , Proteinuria/terapiaRESUMEN
Se presentan 2 series de 25 y 13 trasplantes renales sometidos a inmunosupresión Azathioprina-Prednisona (grupo control) y Ciclosporina-Azathioprina-Prednisona (grupo experimental) en dosis bajas. La sobrevida del injerto renal a 6 y 12 meses es de 88% y 76% para el grupo control, de 100% y 100% para el grupo experimental. Se observó 1 sólo caso de nefrotoxicidad reversible por C y A