[ survey of administration of cherries ethanolic extract on the serum levels of lipids of diabetic rats]

Diabetes mellitus is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both. It is the most common endocrine disorder and by the year 2010, it is estimated that more than 200 million people worldwide will have DM and 300 million will subsequently have the disease by 2025. Tart cherry [Rosaceae] are packed with powerful plant pigments called anthocyanins-which give cherries their dark red color-and it's these compounds one of richest antioxidant sources, lower blood sugar and insulin levels. Adding cherries to the diet also lower the animals' total cholesterol levels and triglycerides. The present study was designed to investigate the effect of Cherries Ethanolic Extract on the Serum Levels of Lipids on Alloxan induced diabetic rats. In this study 36 Male Wistar rats, body weight of 150-200 gr were divided into 6 groups. Diabetes was induced by intra peritoneal injection of 120 mg/kg Alloxan. The duration of the cherries treatment was 30 days. Treatment with extracts of cherries resulted in a significant reduction in triglyceride, LDL, as well as increase in HDL level. Extracts from this plant useful in controlling blood lipids levels. Cherries appear to aid in diabetes control and in reducing the complications of disease

[ comparison effects of analgesics flunixin meglumine and ketoprofen in pain induced by peroxynitrite in guinea-pigs]

Non steroidal anti inflammatory drugs [NSAIDs] are widely used to reduce inflammation, pain and fever. The present study was organized to induce an experimental inflammation in an animal model, using a putative biological oxidant, Peroxynitrite [ONOO] and to study the effects of Flunixin meglumine and Ketoprofen on the pressure-induced pain. For this purpose, 24 male guinea pigs were divided into 4 groups each consisting of 6 animals. Three groups [groups 2, 3 and 4] were injected Peroxynitrite and one group [the first: control] received physiological salt solution subcutaneously in the paw. After induction of a local inflammatory response, Flunixin meglumine [1mg/kg] and Ketoprofen [2 mg/kg] were injected to the second and third groups, 5 times with 12h intervals. The first and the fourth groups were injected saline solution in the same manner. Pressure analgesiometry was performed before and 1 hour after injections. The animals in all 3 groups treated with Peroxynitrite demonstrated an increased sensitivity to painful pressure [P<0.05]. Both NSAIDs decreased the pain sensation dramatically after the 1[st] and the 2[nd] injections but, not after the 3[rd], 4[th] and the 5[th] injections. The study suggested that NSAIDs may be helpful in reducing pressure-induced pain in animal model in early hours of the treatment, whereas the effect subsides over time and ends up after a few days. This effect may be of importance in humans who receive these kinds of drugs for a long period as they may not be effective in reducing pain after a while

Evaluation of the effects ofcurcumin on palm inflammation and level of acute phase proteins in arthritic rats

Rheumatoid arthritis [RA] is a chronic inflammatory disease which is characterized by joint swelling, and synovial inflammation. C reactive protein [CRP] and ceruloplasmin [CP] are identified as important biomarkers of RA and various inflammatory diseases. Curcumin, a widely used yellow color spice is the most active component of Curcuma longa L [Turmeric]. Curcumin contains potent anti-inflammatory and antioxidant properties. The goal of this study is evaluation of the anti-inflammatory effect of curcumin on arthritic palm of rats and levels of the CRP and CP in the blood samples of arthritis induced male albino Wistar rats. Arthritis was induced by subcutaneous injection of Freund's Complete Adjuvant [FCA] into the palm of right rear foot of 8 different male albino Wistar rats. The rats were randomly divided into five groups after the injection. These groups were as follow: Group I, control normal rats, Group II, carrier arthritic rats, Group III, arthritic rats which were given 30mg/ kg of curcumin orally seven days prior to FCA injection, Group IV, arthritic rats treated with 30mg/kg of curcumin, Group V, arthritic rats treated with 3 mg/kg of indomethacin. All the groups except group III received oral treatment with curcumin seven days after FCA injection and the treatment was continued fourteen days thereafter. The rear foot thicknesses of all the rats were measured on days 1, 5, 10, 15, 20 after FCA injection. The rats were destroyed after 20th day and their blood samples were collected. The results of this study indicate that curcumin significantly decreases swelling of the rats rear foot [p < 0.05], and levels of the CRP and CP as compared to carrier arthritic rats [p < 0.05]. One-way variance analysis by ANOVA program and post test analysis by Tukey were used for analysis of the collected data. Evaluation of the results of this experiment supports the anti-inflammatory, and possibly anti-arthritic properties of curcumin in the treatment of RA