[NPM1 and FLT3-[ITD] Gene mutations and laboratory findings in patients with acute myeloid leukemia in Northwest of Iran]

The acute myeloid leukemia [AML] is a malignant disease with an accumulation of the abnormal and undifferentiated blastic myeloid cell in the bone marrow, leading to abnormal hematopoiesis. This study was done to determine the NPM1 and FLT3 [ITD] mutations and laboratory findings in patients with acute myeloid leukemia. This descriptive-analytic study was carried out on 40 [24 males, 16 females] patients with newly acute myeloid leukemia in Northwest of Iran. The mutation of NPM1 and FLT3-ITD were evaluated using PCR method in 25 patients. In all patients, the flowcytometry findings in the bone marrow, leucocytosis and the LDH levels were evaluated prior to the chemotherapy. The mutation of FLT3-ITD and NPM1 genes was detected in 15 [60%] and 9 [36%] of patients, respectively. FLT3-NPM1+ mutation was seen in 4 [16%] patients. Leukocytosis, LDH level and AML in different classes did no show any significant difference between FLT3-NPM1+ and other gene mutations. The mutation of FLT3-ITD gene was nearly twice than NPM1 in acute myeloid leukemia

[Effect of food allergen exculsion on symptoms and quality of life in irritable bowel syndrome]

Irritable bowel syndrome [IBS] is one of the most common gastrointestinal disorders characterized by abdominal pain or discomfort and altered bowel habits. Although IBS etiology is poorly understood, some psychological disturbances and food allergies have been proposed. This study was done to determine the effect of food allergen exculsion on symptoms and quality of life in IBS. In this descriptive and anolytical study was done on 100 IBS patients in Tabriz, Iran during 2011. Food allergies of specific origin and effects of non allergic regimens on quality of life, pain severity and disease symptoms were evaluted during one month period. Data were analyzed using SPSS-16, student's t-test, Chi-Square and Fisher's exact tests. Patients age were 31.5 +/- 7.2 between 15-43 years. Specific antibodies against allergic foods were detectable in 31 [31%] cases. Penaut showed to induce the highest food allergy in 5 [16.1%] patients. The median disease duration was 4.5 +/- 2.6 years in allergic patients while 3.5 +/- 2.9 in non allergic group with no significant difference. The changes is quality of life was significant in non allergic regimens after one month in allergic group [P<0.05] while disease symptoms such as mucus defecation and flatulence had no significant changes. This study showed that one month non allergic regimens reduce abdominal pain and improve quality of life in IBS patients