RESUMEN
Background: Pain is caused by acute or potential tissue damage. Anxiety disorders are common psychiatric disorders in humans that are experienced in threatening situations. Herbal drugs have fewer side effects than chemical drugs
Objective: Evoulution of Hydroalcoholic Extract of Dodoneae viscosa on Pain and Anxiety in Male Rats
Methods: in this study 35 Wister male rats randomly divided in to 5 groups: 1] control group, 2] sham group that received normal saline, 3-5] groups received 100,200,400 mg/kg extract for 10 days by gavages respectively. Pain was tested by formalin test. Anxiety was tested by open filed. Results Dotoneae viscosa extract had a dose-dependent anti-nociceptive effect on chronic pains caused by the formalin injection [P<0.001]. Also check anti-anxiety effects in open box test indicated significant difference in dose of 100, 200 mg/kg extract [effective dose] in Number of passages from the central lines [P<0.001],[P<0.01], Time spend in central line [P<0.001], starch [P<0.001], Grooming [P<0.01], [P<0.05]. 400mg/kg had no effect
Results: According to the presented data, the concentration and amount of silymarin in different extracts was compared. The extract obtained from ground seeds with methanol was able to reach the most amount of silymarin while the highest concentration of silymarin was obtained from the extract of ground pericarp with ethanol 80%
Conclusion: The results indicated that Dodoneae viscosa extract as an antioxidant and anti-inflammatory agent is effective in the treatment of inflammatory diseases and relieving long-term pain such as opioid drugs
RESUMEN
Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxidant property of Ferulago angulata, effect of oral administration of hydroalcoholic extract of this plant was investigated on parameters of the oxidative damage caused by Parkinson's disease in adult rats. Methods: In this research, 40 Wistar rats with the average weight of 200 to 250 g were r and omly assigned to 5 groups, each with 8 rats. Also, to develop Parkinson's disease animal model, 2 of 6-hydroxydopamine drug was injected into medial forebrain bundle on the left side of the animals and the treatment groups received Ferulago angulata extract with doses of 400, 200, and 100 mg/kg for 2 weeks as gavage. Then, the brain of the animals was isolated and parameters of Malondialdehyde and Thiol were measured. Results: Results showed that Parkinson's disease induced significantly increased brain peroxidation lipid, which is one of the factors of oxidative stress, and reduced Thiol level [p<0.001]. Further, treatment of Parkinson's disease with Ferulago angulata extract significantly decreased peroxidation lipid in striatum and hippocampus and increased Thiol level [p<0.001]. Conclusion: oral administration of hydroalcoholic extract of Ferulago angulata probably reduces oxidative damage and also reduces Malondialdehyde and increases Thiol in the treated groups due to its strong antioxidant property