Synthesis and anticonvulsant activity of novel 2-amino-5-[4-chloro-2-[2-chlorophenoxy] phenyl] -1, 3, 4-thiadiazole derivatives

Several novel 2-amino-5-[4-chloro-2-[2-chlorophenoxy]phenyl]-1, 3, 4-thiadiazole derivatives 4a-d were synthesized and their anticonvulsant activity was determined by evaluation of the ability of theses compounds to protect mice against convulsion induced by a lethal doses of pentylentetrazole [PTZ] and maximal electroshock [MES]. The result of anticonvulsant data shows that among the synthesized compounds, 5-[4-chloro-2-[2-chlorophenoxy]phenyl]-N-ethyl-1, 3, 4-thiadiazol-2-amine 4c was the most active compound in both MES and PTZ tests with an ED[50] of 20.11 and 35.33 mg/kg, respectively