RESUMEN
Spleen is an organ that plays a major role in body's immune system and can affect some medicines on it. The purpose of this study is to examine the chronic effect of Methylphenidate on plasma cells and the morphometric and histomorphometric changes in spleen. In this study, a total of 18 adult male mice were divided into one control and two experimental groups. The experimental groups received Methylphenidate 2 and 10 mg/kg body weight, daily by gavage for 40 days. After the treatment, the number of plasma cells, morphometric and histomorphometric changes in spleen and also the weights of mice were studied. The results showed that there is a significant statistical difference between the control and experimental groups in the number of plasma cells, morphometric and histomorphometric structures of spleen and also in the body weight [p<0.05]. The results of this study indicate the harmful effect of Methylphenidate on spleen - an organ that has a major role in body's immune system
RESUMEN
Endocervical microglandular hyperplasia is known as benign proliferation of endocervical glands. Florid form may be mistaken for adenocarcinoma. The patient is a 27-year old female referring when she was during her 37[th] week of pregnancy complaining of decreased movements of her fetus. In vaginal examination a big polypoid and fragile mass was obvious in cervix. The pathological report of the mass was adenocarcinoma. The patient refused further treatment. She safely delivered and consulted her physician 40 days after delivery. In vaginal examination, cervix was completely normal with no mass. Colposcopy and several biopsies from different points of cervix were performed and all reports were endocervical microglandular hyperplasia. She has been followed for 2 years after her delivery and fortunately she has no problem until now