Role of pregablin in neuropathic pain

To evaluate the role of pregablin in neuropathic pain. Prospective descriptive study. This study was conducted in the department of medicine of Al-Tibri Medical College and Hospital from Jan. 2011 to Jan 2012. A prospective study conducted in a private hospital of Karachi from Jan 2011 to Jan 2012. A total 107 cases were enrolled. All patients are adult above 18 years of age. The neuropathic pain was analyzed by Leeds Assessment of Neuropathic symptoms and sign [LANSS]. The pain was assessed by numeric pain rating scale. The data was recorded on a preset performa. Primary disease was also controlled and all the patients were given pregablin 50-150mg/day for two-six weeks. The symptoms were re assess by numeric pain scale. The SPSS 16 used to analysed. Total number of patients were 107. Male were 52 while female were 55. The patients were grouped according to pathology. The most common pathology was Diabetes in 49 cases [45.79%] followed by hypertension in 35 cases [32.71%] and herpes zoster in 27 cases [25.23%]. The age ranges from 42-72 years with mean age is 56.66 +/- 16. The dose ranges from 50-150 mg per day and the duration of treatment were two- six weeks. The pregablin was superior in relieving pain and sleep in patient with diabetic neuropathy and post herpetic neuralgias. The adverse effects noted were somnolence, lethargy and ataxia. Two of the cases were stopped treatment due to somnolence. The result of adding pregablin in the treatment of a patient with neuropathic pain was very successful and it is improving the quality of life and sleep

To evaluate different features of pyogenic liver abscess

To evaluate different features of pyogenic liver abscess. Prospective descriptive study. This study was conducted in the Medical Department of Al Tibri Medical College and Hospital, Karachi from Jan 2011 to Jan 2013. Patient presented with upper abdominal pain and fever of more than two weeks duration. All patients undergone ultrasound of abdomen reported at Al Tibri Medical College and hospital were enrolled in the study. All data was recorded in a preset proforma and features like biodata, symptoms, sign, biochemical test, ultrasonographic finding, culture and sensitivity of pus were assessed. The data were analyzed on SPSS version 15. Total cases were 67. Male were 47 and female were 20. The mean age was 47 +/- 18. With range from 29 to 65 years. Male were more as compared with females. The commonest symptoms were abdominal pain in 43 cases [64%], fever was in 39 cases [58%], anorexia was in 39 cases [58%], Jaundice was in 29 cases [43%], weight loss in 24 cases [37%], raised ESR was in 42 cases [62%], raised leukocyte count was in 57 cases [86%], raised bilirubin in 46 cases [69%] ALT was raised in 27cases [40%] and alkaline phosphatase was raised in 20 cases [29%], ultrasound abdomen showing single abscess in 55 cases [83%] and multiple in 12 cases [17%], right lobe involvement in 53 cases [79%], left lobe involvement in 14 cases [21%], 37 cases [55%] were under gone therapeutic percutaneous ultrasound guided aspiration of the abscess . Culture were positive in 49 cases [73%], in which Klebsella pneumonia was the commonest organism found in 22 cases [45%], Enterococcus supp were in 11 cases [23%], E-coli were in 9 cases [18%], While the culture is negative in 18 cases [27%]. No mortality were recorded. The pyogenic liver abscess is one of the common cause of upper abdominal pain and fever of longer duration