RESUMEN
The present study aimed to explore the relationship of circulating vaspin levels with insulin sensitivity and anthropometric factors. This study was conducted with 65 newly diagnosed type 2 diabetes mellitus [T2DM] patients with age-matched 65 healthy controls. Serum glucose was measured using glucose-oxidase method, lipid profiles by enzymatic end-point methods, and fasting insulin and vaspin levels were assessed with ELISA techniques. Homeostasis model assessment for insulin sensitivity [HOMA%S] and insulin secretory capacity [HOMA%B] were estimated from the fasting glucose and insulin levels using HOMA-CIGMA software. Fasting serum insulin [micro U/ml] was higher in the diabetic group than controls [16.0 +/- 7.9 vs. 10.9 +/- 3.3, respectively, p=0.0001]. The mean [ +/- SD] HOMA%S of the diabetics was significantly lower than that of the controls [48 +/- 31 vs. 76 +/- 55, respectively, p = 0.001]. The HOMA%B of the T2DM group was nearly 50% of that of the controls [71 +/- 40 vs. 131 +/- 46, respectively, p = 0.001]. The T2DM group exhibited significantly lower serum vaspin [ng/ml] levels than the controls [0.62 +/- 0.26 vs. 0.83 +/- 0.28, respectively, p = 0.001]. Vaspin levels were negatively correlated with waist circumference [r = 0.17, p = 0.043] and positively correlated with HOMA%S [r = 0.243, p = 0.007] among all of the participants. The association of serum vaspin with diabetes remained highly significant [p = 0.008] in binary logistic regression analysis performed after adjusting for the effects of confounders. Serum vaspin level is positively associated with insulin sensitivity and negatively correlated with serum glucose, BMI and waist-height ratio
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Serpinas/sangre , Resistencia a la Insulina , Homeostasis , AntropometríaRESUMEN
Objectives: The cytokine visfatin is increased in obesity and type 2 Diabetes; however, its role in the development of diabetes is still unsettled. The present study aimed to investigate the serum visfatin levels in prediabetic subjects
Methods: Seventeen subjects with Impaired Fasting Glucose [IFG], 44 Impaired Glucose Tolerant [IGT], 16 IFG-IGT and 51 healthy subjects were recruited. Fasting insulin and visfatin were measured using enzyme-linked immunosorbent assay [ELISA] techniques. The Insulin sensitivity Homeostasis Model Assessment [HOMA%S] and B-cell secretory capacity [HOMA%B] were estimated using HOMA-CIGMA software
Results: HOMA%B was significantly lower in IFG [p = 0.0001] and IFG-IGT [p = 0.001] subjects. HOMA%S in IGT [p = 0.0001] and IFG-IGT [p = 0.001] subjects were significantly lower compared to controls. The fasting serum visfatin [ng/ml] level was significantly higher in IFG [5.08 +/- 2.16, p = 0.0001], IGT [4.75 +/- 2.81, p = 0.0001] and IFG-IGT subjects [4.33 +/- 2.68, p = 0.013] compared to controls [2.60 +/- 1.2]. In binary logistic regression analysis, visfatin has found significantly associated with IFG [B = 0.198, p = 0.040], IGT [B = 0.162, p = 0.043] and IFG-IGT [B = 0.188, p = 0.044]. Visfatin was also found significantly correlated with postprandial serum glucose and blood pressure in IGT subjects. Frequency of IFG, IGT and IFG-IGT subjects increased with increasing visfatin concentrations
Conclusions: Serum visfatin appear to be associated with IFG, IGT and IFG-IGT. Postprandial serum glucose and blood pressure are positively associated with visfatin levels in IGT subjects