Interaction of capsaicin with mixed function oxidases: exvivo and in-vivo studies

Capsaicin was recently found to alter the in-vitro biphenyl hydroxylation by the 9000 xg supernatent of the liver homogenate of rats. The present work aims at evaluating the effect of subcutaneously administered capsaicin on the ex-vivo metabolism of biphenyl in rats. The produced changes were compared with that of enzyme induction by phenobarbital. In addition, the in-vivo effect of capsaicin on drug metabolism was evaluated by use of the model of hexobarbital sleeping time. It is concluded that subcutaneous administration of capsaicin produces marked activation of drug metabolising enzymes

Influence of capsaicin on enzyme induction by phenobarbital in rats

The present work aims at studying the possible influence of capsaicin on enzyme induction by phenobarbital. A pharmacodynamic model [pentobarbital hypnosis] was utilized for testing the change in enzyme induction. Experiments were performed on adult male Wistar rats. Animals were treated daily for 9 days with phenobarbital alone or together with 1 or 8 mg/kg of capsaicin [p.o.]. All animals received pentobarbital [50 mg per kg, i.p.] one day after the last dosage. The duration of sleep by pentobarbital was reduced by 87.52% under influence of pretreatment with phentobarbital. This percentage was significantly [P < 0.01] reduced as a result of the concomitant administration of capsaicin with phenobarbital. Possible mechanism [s] for this effect are discussed

Influence of capsaicin on drug absorption and transport across biological membranes I Effect on buccal absorption of sulfathiazole

The present work aims at studying the effect of capsaicin on the buccal absorption of sulfathiazole sodium. The study was conducted on 22 volunteers by use of the Beckett-Triggs model of buccal absorption. The absorbed amount of sulfathiazole was significantly higher in eaters of capsicum in comparison with those who do not eat it. The degree of enhancement was much higher in non eaters of hot peppers

Effect of capsaicin on drug absorption and transport across biological membranes III Effect on buccal absorption of glucose

In the persent work, a study was made on the effect of capsaicin on the buccal absorption of glucose by human being. Different incubation periods in the buccal cavity, as well as different concentrations of capsaicin and glucose were utilized. The obtained results indicate an enhancement in the buccal absorption of glucose under influence of capsaicin