Side effects of environmental toxicants: VI-effects of the organophosphorus insecticide sulprofos on serum enzymes and liver of white rats

The acute toxicity in white rats to sulprofos is moderate. The LD50 was 103.3 mg/kg b. wt. for male rats. Degenerative changes, lymphocytic aggregation, hemorrhages and perivascular edema were seen in the liver of sulprofos-treated rats. The clinical biochemistry of serum indicated significant change from control values in the activities of glutamic pyruvic transaminase [GPT], glutamic oxalacetic transaminase [GOT], acid phosphatase, alkaline phosphatase, alpha- naphthyl esterase and cholinesterase [CHE]