RESUMEN
The present study was carried out on 150 women with perimenopausal bleeding and attending the gyneocologic outpatient clinic of Mansoura University Hospital.Endometria 1 brush biopsy was obtained from each women using an endometrial brush. Smears were stained by Papanicolaou stain, thoroughly examined and results were compared to the standard histopathology of function curettage obtained from the same patient. Endometrial hyperplasia was easily identified by cytopathology in 127 cases, out of which 16 cases were histopathologically negative for hyperplastic changes. Eleven suspicious smears were obtained, of which 8 cases were histologically proved to be atypical hyperplasia, or hyperplasia associated with atypical foci. The 3 malignant cases were identically diagnosed by both cytodiagnosis and tissue diagnosis. Collectively, 123 out of the 150 studied cases had a similar diagnosis by cytopathology and histopathology in only 27 cases the cytodiagnosis compared to histodiagnosis was incorrect. On these bases, the authers could recommend the endometrial cytobrush as a safe reliable and efficient out-patient procedure to be initially used for women with perimenopausal bleeding and restrict the invasive fractional curettage to the cytopathologically suspicious cases