Synthesis of some heterocyclic compounds containing naphthalene nucleus for biological evaluation

In this work, 2 mercapto-4-aryl-4H-1,2,3,4,5,6- hexahydrobenzo[h]quianazolines [1] were condensed with alkyl halide to yield the alkyl derivatives II. 3-chloro acetylacetone condensed with compound I in pyridine to yield the thiazoloquinazolines derivatives III. The aminopyrimidine derivatives V were prepared by condensation of aryl methylene-1-tetralone with guanidine hydrochloride. Alpha- tetralone condensed with malononitrile in ethyl alcohol in the presence of beta-alanine to yield 1,2,3,4-tetrahydronaphtho-alpha- yiledene malononitrile VII. Compound VII added one mole of aromatic aldehyde in ethanol in presence of potassium hydroxide to yield 2-imino-10-aryl-8,9-dihyronaphtho[1,2-d] pyrano-3-carhonitrile VIII. Compounds VIII were reacted with ammonium acetate in acetic acid to yield 2-amino-10-aryl-3,9-dihydronaphtho[l,2-d]-3-carbonitrile IX. Compounds IX were prepared directly from VII by the action of appropriate aromatic aldehyde and ammonium acetate in acetic acid

Studies on ketene s,s,acetals. Part 1. synthesis of new pyrazol [1, 5 - 1] - pyrimidines and pyrazolo [1,5-a] triazines utilizing ketene s,s, acetals

In the present work, the new 3 [p-haloarylamino]4-methoxycarbonyl-5- aminopyrazole [3a-c] were obtained by using ketene S,S,acetal derivatives [1] as good precursors for the synthesis of p- haloarylaminomethoxycarbonyl methyl mercaptal [2a-c], which were prepared through displacement reaction of cyanomethoxycarbonyl ketene dithioacetal [1] with amines. The results of the study were given