Postprandial hyperinsulinaemia and growth of human hepatocellular carcinoma

Human liver cirrhosis is commonly associated with increased fasting and glucose induced insulin concetrations. The main cause of impaired glucose metabolism in chronic liver disease is a reduced insulin action. Patients with chronic liver disease complicated with human hepatocellular carcinoma [HHC] frequently have impaired glucose metabolism. Aim: To investigate the effect of augmentation of postprandial hyperinsulinaemia on the growth of hepatocellular carcinoma. Patients and methods: The growth rate of 60 small hepatocellular carcinomas [diameter 140 days, n=30]. Fasting plasma insulin concentration and area under the plasma curve [AUCins] of oral glucose tolerance test [10.3[6.3] mirco U/ml and 265 [159] mirco U/ml/h, respectively; [mean [SD] in the rapid growth group were significantly higher than those in the slow growth group [7.7[4.5] mirco U/ml/h and 153 [145] mirco U/ml/h], respectively] [p= 0.031, and 0.0005], respectively. In contrast, Fasting plasma glucose concentration and area under the plasma glucose curve [AUCglu] in the rapid growth group were significantly lower than those in the slow growth group [p=0.0002 and p=0.001, respectively]. Initial tumor size was significantly higher in rapid growth than in the slow growth with p=0.01. Univariate and multivariate analyses of logisitic regression models demonstrated that AUCins was a significant factor contributing to the growth rate of HCC [p=0.001 and p=0.015, respectively]. Conclusions: The real time ultrasonography appears to offer a simple, safe, and noninvasive method of monitoring the growth rate of hepatocellular carcinoma. The postprandial hyperinsulinaemia is significantly correlated with the rapid growth of human hepatocellular carcinoma; accordingly octreotide[long acting somatostatin analogue] can be used in the treatment of inoperable hepatocellular carcinoma

Studies of the complexes of Co2 +, Cu2+ and Zn2+ with oximes and Schiff's base derivatives of N-Furoylphenylhydroxylamine

The nature of the bond between the ligand and metal ion, the composition and also stability constants of the title chelates using IR, 1H-NMR, UV-visible-spectra, conductometric and potentiometric titrations were studied