Serum lipoprotein [LP[a]] levels in patients with diabetes mellitus and impaired glucose tolerance: an evaluation and comparison

Lipoprotein [a] [Lp[a]] is known as an independent risk factor of atherosclerosis and changes in serum level of this molecule and other lipoproteins have been noticed in diabetic patients because the most important cause of death in these patients is related to their cardiovascular disorders. Moreover, patients with IGT [Impaired Glucose Tolerance] are more at risk of cardiovascular disease than the normal population. The main purpose of this study is to comparie Lp[a] serum levels between diabetic patients, patients with IGT and normal controls without any glucose metabolism disturbance. In this study, 180 patients [112 females, average age of 51 +/- 11 years and 68 males, average age of 54 +/- 14 years] were selected and placed in three separate age and sex matched groups [60 patients in each group] as Diabetic, IGT and Control group. After taking clinical history and determining body measurements, serum total cholesterol, triglyceride, HDL-C, LDL-C and Lp[a] were measured in fasting blood samples. Lp[a] serum levels were not significantly different between the three groups. [DM:25.4 +/- 20.9, IGT: 24 +/- 21.4, Control: 24.6 +/- 17.9 mg/dL]. An increase in serum triglyceride was found in the diabetic patients compared with the controls. [DM: 210.6 +/- 91.5, control: 159 +/- 71.9 mg/dL p = 0.04]. HDL-C levels showed no significant difference between groups. In addition, HDL-C levels of the all three groups were lower than the recommended range of Coronary Artery Disease prevention. [average range of the three groups: 37.4 +/- 8.7 mg/dL] Total Cholesterol and LDL-C serum levels were higher in diabetic patients compared with the controls. [DM: 222.3 +/- 35.4 vs Control group: 191.7 +/- 46.5 mg/dL p < 0.007 and DM: 141.2 +/- 32.4 vs Control: 119.0 +/- 36.6 mg/dL p < 0.03]. In the IGT group, serum lipids levels were between the levels of the diabetic and control groups none of these differences were significant. This study shows that Lp[a] serum levels do not change in Diabetes Mellitus and IGT

[Type of fatty acid intake, serum lipid and lipoprotein levels in relation to creatinine and GFR]

Correlation between, fury acids intake, serum lipid und lipoprotein with .serum creatinine and kidney function in patients with renal, failure has been suggested by other investigators. This relationship has not been reported, for all types of fatty acids. This study was conducted to determine the association of the consumption of different type of fatty acids, serum lipids and lipoproteins with serum creatinine and glomerular filtration rate [GFR] in healthy adult subjects residing in district 13 of Tehran. There were 15003 subjects participated in TLGS. 1470 persons were 1-undotnly selected for nutritional assessment. After excluding under- and over-reporter 486 subjects aged over 20 years remained in the study. Dietary data were collected by two 24-hour dietary recalls. Serum creatinine, total cholesterol, triglyceride and HDL were measured by Selectra 2 autoanalyzer after 12hour fasting. GFR was calculated based on serum creatinine. Mean [+/-SD] of serum creatinine, cholesterol, triglyceride, HDL and LDL levels and GFR were 1.04+/-0.16. 201+/-41. 153+/-125. 43+/-10. 128+/-37 mg/dl and 99+/-19 ml/min respectively. Subjects with saturated fatty acids intake of more than 10 percent of calorie had higher levels of serum creatinine versus the others [P>0.01. 10+/-0.009 vs 1.03+/-0.2]. People with oleic and linoleic acid intake of more than 10% and 1% of calorie respectively, had higher levels of serum creatinine and GFR [P<0. 01]. There were significant correlations between serum cholesterol, LDL. HDL, and triglyceride with serum creatinine [p<0.05, p< 0.05, p<0.001, p<0.001 respectively]. According to observed correlations the control of intake of desirable amount of fatty acids to desirable amount of fatty acids and serum is lipid and lipoprotein level is necessary for renal health