Mercury[II] cystine complex as antineoplastic agent

Antineoplastic activity of mercury[II] cystine complex was studied against ehrlich ascites carcinoma [EAC] cells in Swiss Albino mice. Cell growth inhibition, increase of life span, haematological parameters, alkaline phosphatase activity of tumour bearing mice inoculated with EAC cells were studied with the test compound. It was found that this compound significantly inhibited the tumour cell growth, enhanced life span of the tumour bearing mice at dose 6 mg/kg i.p. Such treatment also restored the altered haematological parameters and serum alkaline phosphatase activity very closely towards normal. The compound can be considered as a potent antineoplastic agent

Antineoplastic activity of nickel [II] cystine complex against ehrlich ascites carcinoma in swiss albino mice

Ni[II]-cystine complex was synthesized by treating saturated aqueous solutions of Ni [II] acetate and L[-] cystine [in 1: 1 molar ratio]. The complex was used to study its antineoplastic activity against EAC cells in Swiss Albino mice. It was found that the Ni [II] complex restored the depleted haematological and biochemical parameters of the EAC bearing mice towards normal values and enhanced the longevity of such mice significantly. The test compound on the other hand showed negligible host toxicity. The results obtained were compared with those obtained with a standard anticancer drug bleomycin

Intracellular killing in compromised host

Defective ICK of live Candida albicans was found in patients with chronic renal failure, diabetics and in bilharzial hepatic fibrosis. In diabetics the intracellular killing was found to be impaired irrespective of complications or short term control of the diabetic state. This defect was proved to be a primary cellular defect. In bilharzial hepatic fibrosis the defect was more in patients with hepatocellular insufficiency. This defect was explained by an extracellular factor [s] mainly. The significant improvement obtained by haemodialysis in chronic renal failure denotes the presence of extracellular partially dialysable toxic substances. However a primary cellular defect was also detected