significance of latent hyperbilirubinemia

This work was conducted on 514 apparently healthy individuals [341 males and 178 females] aged 20-35 years. All individuals were subjected to thorough history taking with special stress on negative history of schistosomiasis and its treatment, acute or chronic hepatitis, blood transfusion or its products, repeated exposure to possibly hepatotoxic agents, operative interference and of being at a high risk for catching hepatitis, e.g. patients on chronic hemodialysis, surgeons and dentists. Thorough clinical examination was done for all individuals to exclude general and local signs of hepatic affection and splenomegaly

effect of oxamniquine therapy on the electrocardiogram and echo cardiogram in patients of active hepatosplenic bilharziasis with and without bilharzial cor-pulmonale

The material of this work comprised 25 cases with active intestinal bilharziasis associating bilharzial hepatosplenomegaly with and without cor-pulmonale. All patients were given pxamniquine with a total dose of 60 mg/kgm body weight twice daily for three successive days. All patients were subjected to Biochemical and haematological studies as well as E.C.G. and echocardiography before, one week and one month after oxamniquine. Compacatative electrocardiography though revealing nonsignificant changes as regards the E.C.G. parameters as minor incidence% of S-T and T wave changes and arrhythmia one week after oxamniquine therapy, corrective reversbility in these parameters was the rule. Echocardiographic assessement for left ventricular performance and for indices of myocardial contractility revealed non significant changes short of denoting left vnetricular dysfunction one week after oxamniquine and moreover reversibility pattern for these changes was evident one month after therapy. A non-significant increase in the pulmonary arterial pressure was observed one week after therapy to diminish one month later on. Non-significant aberrations in liver and renal functions as well as non significant increase in HB, R.B.C.S. and W.B.O.S. were observed one week after therapy together with corrective reversibility for these aberration were demonstrable one month later. Cure rate after oxamniquine therapy was 80% in group of hepatosplenomegaly and in the group of compensated bilharzial cor-pulmonale and 60% in decompensated group of bilharzial cor-pulmonale. A suggestion for further work can be targeted towards a comparative evaluation for efficacy and safety of this drug in therapy of active bilharziasis in compensated and decompensated cardiac patients with cardiac disorders aetiologically non-related to bilharzial infection

Q-TC interval variations after portal decompression with different shunt operations in hepato-splenic schistosomiasis

1: 23 patients of hepato-splenic bilharziasis with history of ruptured oesophago-gastric varices belonging to child's classification A. were subjected to portal decompression by shunt operations comprising 5 patients for interposition mesocaval shunt and 18 for distal Lieno-renal. 2. Pre-operative biochemical, hematologic, electrolytes, radiology, endoscopic E.C.G. and pathology studies as well as percutaneous trans-splenic portal manometry were carried out for them. 3. Post-operative biochemical and E.C.G. assessement were done for all patients. Follow up portal manometry for patients subjected to mesocaval operation and endoscopic assessement of the varices for patients subjected to Warren's operation were done to evaluate portal decompression. 4. An important comparative follow up E.C.G. finding was progressive significant shortening of Q-1c interval 3 and 6 months after Warren's, but not mesocaval operations, the causes of which were discussed. 5. Such finding can offer valuable achievement as regard assessment of emodynamic efficacy of the type of shunt concerning portal decompression portal perfusion, a non-invasive E.C.G. follow up tool to evaluate persistance of shunt patency and finally a possible indicator for shunt occlusion