Effect of methionine on doxycycline induced hepatotoxicity in albino rats

To study the effect of methionine in doxycycline induced hepatotoxicity in relation to body weight and liver weight in albino rats. The body weight and liver weight were measured in thirty male albino rats of six weeks age, after methionine therapy in doxycycline induced hepatotoxicity. It was observed that there was significant increase in body weight and non-significant change in liver v/w ratio. It is concluded that methionine antagonizes the hepatotoxic effect of doxycycline

Effects of ciprofloxacin on foetal hepatocytes

To evaluate the hepatotoxic risk of Ciprofloxacin administration during gestation on Wistar albino rat foetuses. An animal study carried on experimental pregnant female Wistar albino rats and their foetuses in the department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Ciprofloxacin was administered to pregnant Wistar albino rats at a dose of 20 mg/kg body weight intraperitoneally [twice the therapeutic dose] from day-8 to day-18 of gestation. The intact rat foetuses were isolated on day-18 of gestation. These animals were killed by deep ether anaesthesia. Liver removed, weighed and fixed in 10% formalin, embedded in paraplast, 3 micro m thick sections were cut on rotary microtome, and stained with haematoxylin and eosin. The histomorphological features of liver were compared with those of control animals and analyzed statistically. The study revealed that prenatal Ciprofloxacin produced degenerative changes in liver of foetuses. The results strongly suggest that Ciprofloxacin, given during pregnancy, causes severe liver damage in foetuses of Wistar albino rats