RESUMEN
Diabetic nephropathy [DN] is a severe complication of diabetes which may progress to end-stage renal disease [ESRD]. Chronic hyperglycemia is considered as the major initiator of DN, either by creation of oxidative stress or by induction of growth factors and cytokines. Moreover, dyslipidemia plays a role in DN progression. The aim of our study was to examine the changes in lipid profile, malondialdehyde [MDA], transforming growth factor- beta1 [TGF-beta1] and angiotensin II [Ang II] levels in type 2 diabetic patients associated with kidney disease. Diabetic microalbuminuric [n=25] and macroalbuminuric [n=15] patients showed significantly higher levels of blood glucose, glycated hemoglobin [HbA1c], triglycerides [TG], total cholesterol [TC], MDA, TGF- beta1 and Ang II than either diabetic normoalbuminuric [n=14] or control [n=16] subjects. In the microalbuminuric and macroalbuminuric diabetic groups, albumin excretion rate [AER] was positively correlated with MDA [r=0.448, p < 0.01], TGF- beta1 [r=0.81, p < 0.01] and Ang II [r=0.772, p < 0.01]. Additionally, MDA correlated with TGF- beta1 [r=0.625, p < 0.01] and Ang II [r=0.428, p < 0.01]. In conclusion, dyslipidemia, oxidative stress, and increased TGF- beta1 and Ang II are associated with DN in type 2 diabetic patients