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3.
Indian J Physiol Pharmacol ; 1979 Jan-Mar; 23(1): 1-7
Artículo en Inglés | IMSEAR | ID: sea-108607

RESUMEN

Creatinine, an aminoacid, has been studied for its anti-inflammatory activity. It is orally effective in suppressing the inflammatory responses produced by carrageenan, 5-hydroxytryptamine, nystatin and formaldehyde. It is observed that the antiinflammatory effect of creatinine is not owing to counter irritant action. It is suggested that it may partially be mediating its anti-inflammatory activity by interfering with the action or/and synthesis of prostaglandins. Like phenylbutazone it also possesses an analgesic action.


Asunto(s)
Enfermedad Aguda , Administración Oral , Analgésicos/farmacología , Animales , Antiinflamatorios , Carragenina/farmacología , Enfermedad Crónica , Creatina/farmacología , Creatinina/administración & dosificación , Evaluación de Medicamentos , Edema/tratamiento farmacológico , Femenino , Formaldehído/farmacología , Inflamación/inducido químicamente , Masculino , Nistatina/farmacología , Fenilbutazona/uso terapéutico , Antagonistas de Prostaglandina , Ratas , Serotonina/farmacología
5.
Indian J Exp Biol ; 1978 Jul; 16(7): 834-6
Artículo en Inglés | IMSEAR | ID: sea-61212
6.
Indian J Physiol Pharmacol ; 1978 Jan-Mar; 22(1): 93-7
Artículo en Inglés | IMSEAR | ID: sea-106502

RESUMEN

Diethylcarbamazine (DEC) produced an initial stimulation followed by depression of the movements of the intact worm and nerve-muscle preparation of Setaria cervi. The effective concentration of DEC was reduced to one hundredth in the nerve-muscle preparation as compared to the whole worm, suggesting that the cuticular barrier is highly effective in preventing the penetration of the drugs. The depressant effect of DEC was concentration dependent and was not reversed even after repeated changes of the bath fluid. The worms consumed 7.7 mg +/- 0.2 glucose/g wet weight/hr. The consumption of glucose was directly proportional to its motor activity; it increased during the stimulant phase with low doses of DEC and decreased during the depressant phase.


Asunto(s)
Animales , Dietilcarbamazina/farmacología , Filarioidea/efectos de los fármacos , Glucosa/metabolismo , Movimiento/efectos de los fármacos , Setariasis/parasitología
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