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Abstract Objective To evaluate the immunoexpression profile for CD8, CD3, CD20 and CD68 in the process and carcinogenesis of Carcinoma of the vermilion lip. Methods Average cell count with positive expression for CD3, CD8, CD20 and CD68. The CD8/CD3 ratio calculated in the region was based on the percentage of positive cells in a total of malignant cells. Kruska-Wallis/Dunn, Mann-Whitney and Spearman correlation tests (SPSS, p< 0.05) were used. Results In the Aquitic Cheilitis samples, there was an increase in intraepithelial CD8+ and CD68+. In LSCCs, there was an increase in peritumoral and intratumoral CD3+, CD8+, CD20+ and CD68+ cells. In peritumoral LSCC, CD3+ and CD8+ showed a direct correlation (p= 0.004), and CD68+ and CD8+ (p= 0.017). In the intraepithelial region, CD8+ correlated with CD20+ (p= 0.014) and CD68+ (p= 0.013). In the CAs, CD3 (p< 0.001) and CD8 (p= 0.025) correlated intraepithelial and subepithelial. In LSCC CD3+ (p= 0.002), CD8+ (p= 0.001) and CD68+ (p= 0.030) had intra and peritumoral correlation. Conclusion CD68+ is the first interacting cell with the greatest capacity to migrate to the tumor and interact with CD3, CD8 and CD20. Apparently, CD20 affects perineural invasion. Level of evidence: Level 2.
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ABSTRACT Objective: To evaluate the prevalence of dental caries in children aged five years in a Northeast Brazilian Capital (Fortaleza, CE) and its association with sociodemographic conditions, presence of malocclusion, and gingival bleeding. Material and Methods: This is a quantitative, descriptive, observational, and cross-sectional study carried out in a representative sample of 3,582 children aged five years in the city of Fortaleza-CE. Data was collected in public and private schools distributed in the city's Regional Health Coordination (CORES). Each of the six CORES worked with five field teams, participating in inter-examiner training and calibration with a final KAPPA coefficient of 0.87. Data were collected using a clinical form adapted from the SB Brasil 2010 questionnaire on sociodemographic conditions. The indices of dmft, need for treatment, malocclusion, and gingival bleeding were used for oral health conditions. The data were submitted to Pearson's Chi-square or Fisher's Exact tests, and the variables that show values of p<0.05 were submitted to a multinomial logistic regression model (forward stepwise model). Results: 57.1% of children were caries-free, and the mean dmft-d was 1.65 (1.65±2.65). CORES I and VI were the ones that presented the most significant association with caries attacks in all primary molars. The highest percentage of caries in the 2nd upper molar (60.6%), 1st lower molar (59%), and 2nd lower molar (58.8%) were found in children with normal occlusion. There was a significant association between gingival bleeding and caries in all molars and the need for treatment. Conclusion: These results allow us to observe that the prevalence of dental caries in 5-year-old children in Fortaleza is low, although with a tendency to increase.