Basal cell carcinoma, odontogenic cysts, brain and skeletal abnormalities (Gorlin Goltz Syndrome) in a 46-year-old woman

@#<p style="text-align: justify;"><strong>OBJECTIVE:</strong> To present the case of a 46-year-old woman with basal cell carcinoma, odontogenic cysts, brain anomalies and skeletal abnormalities.<br /><strong>METHODS:</strong><br /><strong>Design:</strong> Case Report<br /><strong>Setting:</strong> Tertiary National University Hospital<br /><strong>Patient:</strong> One<br /><strong>RESULTS:</strong> A 46-year-old woman consulted for a non-healing, necrotic left orbital ulcer that started as a skin-colored, papilla-like lesion on the upper eyelid. There were also hyperpigmented lesions with ill-defined borders over both paranasal areas. Tissue biopsies revealed basal cell carcinoma. Radiologic imaging showed cystic lesions in the mandible, straightening of cervical vertebrae and calcifications of the falx cerebri, tentorium cerebelli, pineal gland and choroid plexus. Based on established major and minor clinical and radiologic criteria, we arrived at a diagnosis of Gorlin Goltz Syndrome or Nevoid Basal Cell Carcinoma Syndrome (NBCCS). She underwent wide excision of the left orbital mass with exenteration, excision of left and right paranasal masses, left total parotidectomy with facial nerve preservation, enucleation of mandibular cyst and cervicofacial reconstruction with skin grafts of the left orbital area and ala.<br /><strong>CONCLUSIONS:</strong> NBCCS is a rare autosomal dominant disorder with a high tendency for neoplasms and developmental anomalies. Diagnosis can easily be missed if the physician is unaware of its classic but bizarre presentation. Early recognition and prompt specialist referral is very important in order to prevent complications and provide better prognosis. Patients should be reminded of the importance of follow-up as other presentations of the syndrome may manifest later in life and family genetic screening and counseling should be undertaken.</p>

Basal cell carcinoma, odontogenic cysts, brain and skeletal abnormalities (Gorlin Goltz Syndrome) in a 46-year-old woman

OBJECTIVE: To present the case of a 46-year-old woman with basal cell carcinoma, odontogenic cysts, brain anomalies and skeletal abnormalities.METHODS:Design: Case ReportSetting: Tertiary National University HospitalPatient: OneRESULTS: A 46-year-old woman consulted for a non-healing, necrotic left orbital ulcer that started as a skin-colored, papilla-like lesion on the upper eyelid. There were also hyperpigmented lesions with ill-defined borders over both paranasal areas. Tissue biopsies revealed basal cell carcinoma. Radiologic imaging showed cystic lesions in the mandible, straightening of cervical vertebrae and calcifications of the falx cerebri, tentorium cerebelli, pineal gland and choroid plexus. Based on established major and minor clinical and radiologic criteria, we arrived at a diagnosis of Gorlin Goltz Syndrome or Nevoid Basal Cell Carcinoma Syndrome (NBCCS). She underwent wide excision of the left orbital mass with exenteration, excision of left and right paranasal masses, left total parotidectomy with facial nerve preservation, enucleation of mandibular cyst and cervicofacial reconstruction with skin grafts of the left orbital area and ala.CONCLUSIONS: NBCCS is a rare autosomal dominant disorder with a high tendency for neoplasms and developmental anomalies. Diagnosis can easily be missed if the physician is unaware of its classic but bizarre presentation. Early recognition and prompt specialist referral is very important in order to prevent complications and provide better prognosis. Patients should be reminded of the importance of follow-up as other presentations of the syndrome may manifest later in life and family genetic screening and counseling should be undertaken.

Food Preferences and Dietary Intakes of Filipino Adolescents in Metro Manila, The Philippines

Introduction: This study examined differences in food preferences and dietary intake among male and female Filipino adolescents of different nutritional status as measured by body mass index (BMI). Methods: One hundred and twenty 13- 17-year olds from various schools and communities in Metro Manila, The Philippines were selected through quota sampling with BMI, sex and age as criteria. Data on mean dietary intake and food preference were collected using pretested instruments - a 3-day food record and a food preference questionnaire, respectively. Resulting values were analysed using one-way ANOVA, Bonferroni test and Pearson’s product-moment and Spearman’s correlation using SAS Enterprise Guide version 2. Results: Preference for cereals prepared with added sugar or fat (ρ=0.21, p= .0240), and low fat meat (ρ=0.18, p=0.420) were found to be positively correlated with BMI, while preference for fruits that are high in vitamin A (ρ= -0.18, p=0.430) was negatively correlated with the said variable. Overweight respondents gave lower and significantly different preference scores to donut (p=.02780), banana cue (p=.0489) and mayonnaise (p=.0291). Respondents of different nutritional status also had statistically different intakes of fibre, calcium and phosphorus, corresponding with the positive correlation of fibre (ρ=0.25231, p=0.0054), calcium (ρ=0.2529, p=0.0134) and phosphorus (ρ=0.25887, p=0.0043) intake with BMI. With respect to sex, male respondents gave statistically higher preference for French fries (p=.0370), tofu (p=.0005), garlic (p=.0190) and mussels (p=.0023). Also, males have significantly higher intakes of energy and carbohydrate than female respondents. Conclusion: Results suggest that food preferences should be considered in the nutritional care management of malnourished adolescents.