Orchidectomy versus Orchidectomy plus cyproterone acetate in the treatment of metastatic prostatic carcinoma

This study included 42 patients all underwent orchidectomy and only 22 received cyproterone acetate in a dose of 150-200 mg PO daily. Clinical, laboratory and radiological evaluations were done during the period of the study [from January 1992 to June 1997 inclusive]. There was no high difference in the causes of death. The mean overall survival was longer in the combined treatment group [44.9 m vs. 36.9 m]. Time to disease progression was significantly longer in the combined modality group [30.7 m vs. 22.7 m]. Hot flushes were less in the combined group [31.0% vs. 60.6%] but the difference was insignificant