RESUMEN
Human T-cell Lymphotrophic virus type 1 [HTLV-1] has infected more than 20 million people worldwide. Northeast of Iran, Mashhad, the capital of Razavi Khorasan Province, is endemic for HTLV-1 with a prevalence of 3% among general population. We evaluated the ICSI outcome in our program for [HTLV-1] serodiscordant couples [SDCs] with the female infected in comparison with control group. This study was performed between 2007 and 2011 in Novin Infertility Treatment Center [Mashhad, Iran]. We examined 32 ICSI cycles of HTLV-1 infected women in comparison with an age matched control group [n=62]. ICSI outcome was compared regarding fertilization rate [FR], embryo quality parameters, implantation rate [IR], clinical pregnancy rate [PR], and abortion rate [AR]. Fertilization [p=0.15], implantation [p=0.33], and pregnancy rate [p=0.12] were similar between the groups. No difference was found regarding the number of transferred embryos [on day 2 or 3] and cryopreserved embryos, multiple pregnancies, or abortion rates between the groups. Our results suggest that the embryo quality and ICSI outcome are not affected by HTLV-1 infection in serodiscordant couples. The major finding of this study is that the outcome of ICSI in HIV-I-infected patients and seronegative controls is similar.