RESUMEN
The age-dependent worsening of lipid profiles increased the risk of cardiovascular disease in males. Eating fruits and vegetables is known to be beneficial on lipid profile. The objective of this research was to delineate whether drinking daily squeezed apple juice [AJ] modulates lipid profile and antioxidant enzymes in the animal model that gonadectomized. In this experimental study, 28 male rats were equally divided among the following 4 groups: group I [control], orchidectomized [ORX], ORX +AJ 10%, and ORX+ AJ 25%. After 60 days of drinking AJ, superoxide dismutase [SOD], alkaline phosphatase [ALP], cholesterol, LDL, HDL and triglycerides in serum were evaluated. Data analyzed by SPSS-16 and computed using one way ANOVA followed by Tukey multiple comparison test. P < 0.05 was statistically significant. In the ORX group compared with the sham group serum SOD and ALP activities decreased [P < 0.05], while serum cholesterol, triglycerides, LDL increased but HDL decreased in ORX groups [P < 0.05]. In contrast to the ORX group, drinking AJ decreased [P < 0.05] concentration of LDL, TG and cholesterol in the serum. AJ also increased [P < 0.05] serum HDL, SOD and ALP activities compared with the ORX group
RESUMEN
Diabetes mellitus is recognized with severe complications. Many herbal medicines have been recommended for treatment of diabetes problem. In this study, the effect of hexanic and alcoholic extracts of fenugreek [Trigonella-foenum graecum] on serum parameters was investigated in normal and streptozotocin-induced diabetic rats. This experimental study was carried out in 2011 at paramedical school of Guilan University of Medical Sciences, 48 male Sprague Dawley rats [230- 300 gram] were divided into six groups: control, type 1 diabetic, and 2 diabetic groups that receive alcoholic extract and 2 groups receive hexanic extract of fenugreek [100, 200 mg/kg body weight] intraperitonealy for 28 days. For diabetes induction, streptozotocin [60 mg/kg/ intraperitonealy] was used. Blood glucose, total cholesterol, triglyceride [TG], urea, creatinine, uric acid, AST and ALT level was measured. Data were analyzed with spss software 16 and One Way ANOVAs and Tukey test. p<0.05 was statistically significant. Fenugreek extract inhibit weight loss especially in diabetic groups that receive hexanic extract [p=0.006]. blood glucose, total cholesterol, TG, urea, creatinin, uric acid, AST and ALT level was reduced significantly in diabetics groups that receive fenugreek extract [p=0.001]. This effect was stronger in groups that receive Hexanic extract. Fenugreek is a good candidate for reduction of diabetic complications