Micronucleus assay in patients with lung cancer, chronic obstructive pulmonary disease and non-smoker control

This study included 96 male subjects; 40 patients with lung cancer, 36 patients with chronic obstructive pulmonary disease [COPD] and 20 control subjects. 25% of cases with lung cancer and 86.1% of cases with COPD had micronucleus [MN] frequency ranging <5-<15 MN/500 cytokinesis blocked [CB] binucleated cells compared with 100% in the control group. 40% of cases with lung cancer and 13.9% of cases with COPD had 15-20 MN/500 CB binucleated cells. 35% of cases with lung cancer had 20-25 MN/500 CB binucleated cells. These differences were statistically significant. In the lung cancer group, the mean MN/500 CB binucleated cells was 18.4 +/- 4.2, in the group with COPD, it was 8.3 +/- 4.1 with 8 patients having MN in the cancer range, i.e. 12-17. The mean MN/500 CB binucleated cells in the control group was 5.4 +/- 2.5. These differences were statistically significant. All cases with lung cancer and 63.9% of cases with COPD had a mean MN frequency greater than 95% CI of the mean MN frequency for the control group. Applying logistic regression analysis for the effect of risk factors revealed that lung cancer patients, who were current or ex- smokers, had significantly higher MN frequencies than patients with COPD

Endoscopic sclero-therapy [ES] in the treatment of bleeding gastric varices

Of 154 patients with portal hypertension gastric varices was found in 24 [16S percent]. While the majority [87.5 percent] of patients had gastric varices in association with oesophageal varices, 3 [12.5 percent] patients had isolated gastric varices. Cyano-acrylate glue was used in a 3 week schedule. Variceal obliteration was achieved in 6 patients [25 percent] and reduction in size was noted in another 4 patients [16.6 percent]. No change was noted in 8 patients [33.3 percent]. There were 6 deaths [25 percent] 4 due to uncontrolled bleeding and 2 due to hepatic coma. It is concluded that Gastric Variceal sclerotherapy [GVS] should be attempted .for bleeding gastricc varices. The definitive treatment is surgical decompression

Pathological study of clinically diagnosed benign breast masses

120 female patients presented to Al Azhar University Hospital with a lump in the breast which was diagnosed as a benign mass on clinical examination. All masses were sent for histopathological examination, the incidence of malignancy in the clinically diagnosed benign masses was 12.5%. Fibroadenomas were the commonest masses encountered in the study and forms 47.5%, fibrocystic disease was the second infrequency and from 30% of the cases. Malignant lesions were the third infrequency and form 12.5% of cases followed by non specific mastitis which forms 5% of cases, there was 2 cases of glactocele and 2 cases of duct ectasia, 2 cases cytsoarcompaphylloids. and one case of intraduct papilloma

Early post-operative endoscopic papillosphincterotomy [EPT] for retained common bile duct stones

The results of endoscopic papillo sphincterotomy [E.P.T.] in 15 patients with retained common duct stones and T-tube in situ following surgical exploration of the common bile duct are presented. Successful stone extraction was achieved in 12 patients [80.0%]. Early post-operative T-tube cholangiography is advocated and if necessary endoscopic papillo-sphincterotmy [E.P.T.] can be safely performed 10 days following surgery. This approach is an effective and safe method in the early post-operative period allowing rapid treatment during the same admission and shorting of the hospital stay

Endoscopic sclero-therapy with or without propranolol in prevention of recurrence of variceal bleeding; a prospective randomized controlled trial

Endoscopic sclero-therapy [E.S.] and continuous propranolol treatment [P.] have both been proposed as useful methods to prevent recurrenc of variceal bleeding. We report a prospective randomized trial in 80 patients with previous history of endoscopically proven esophageal variceal bleeding. Patients were randomized for child's A and B groups to receive either endoscopic sclero-therapy or E.S. with propranolol. The dose of propranolol was based on a reduction of the resting pulse rate by 25%. Combined intra variceal and paravariceal sclero-therapy of 5% ethanolamine oleate was used in a 3 - week schedule. The follow-up period ranged from 12 - 28 months. The percentage of patients free of variceal rebleeding after inclusion were 80% in the endoscopic sclero-therapy [E.S.] group and 95% in the combined group