Rupture Ectopic Pregnancy in Early Gestation Due to Mifepristone & Misoprostol Abuse

Ectopic pregnancy is a significant health problem in the world,which affect 1.2% of women of reproductive age; causingsignificant morbidities and mortality. Most ectopic pregnanciesare located in the ampullary, fimbriae or isthmic part of thefallopian tube. Mifepristone (antiprogesteron) followed by a lowdose of Misoprostol (prostaglandin E1, analogue) has beenused for medical termination of early pregnancy after embryoreaching endometrial cavity. But there have been many reportsof misuse of this combination drug. Here we report- fifteencases of rupture ectopic pregnancy after misuse ofcombination drug in very early pregnancy as an over thecounter drug without looking for ectopic pregnancy.