RESUMEN
Nowadays, various antibiotics and antiseptics are used as locally delivered adjuncts to scaling and root planing [SRP] in the treatment of periodontitis. The aim of this study was to evaluate the clinical efficacy of xanthan-based CHLO-SITE gel [xan-CHX] as a local adjunctive therapy to SRP in the treatment of moderate-to-severe periodontitis. In this controlled clinical trial, 6 patients with moderate-to-severe chronic periodontitis were selected. Each subject had at least three pockets 4-7 mm deep. Twenty-eight randomly selected pockets were assigned to the control group and 44 pockets were assigned to the test group. Scaling and root planing [SRP] procedures were carried out in all the pockets. In the test group, in addition to SRP, xan-CHL gel was injected into the pockets. Clinical indices [PPD, CAL, BOP, PI] before and three months after treatment were measured and evaluated by paired t-test, chi-squared and Kruskal- Wallis tests using SPSS software. At baseline, there were no significant differences between the control and experimental sites in relation to the indices measured. After 3 mouths, means of PPD and BOP in the experimental sites were significantly lower compared to control sites [p value