RESUMEN
Polycystic ovarian disease is one of the most common causes of hirsutism, irregular menstruation, obesity, anovulation or infertility in women. More than 50% of these women become obese and 1/3 of them diabetic at a time throughout the life. Metformin is useful to improve the insulin resistance, hirsutism and oligomenorrhea of PCOS patients. Administrating spirinolactone as an androgen antagonist in conjunction with a contraceptive pill such as Cyproterone compound [Dian] may also be effective to treat the sings and complaints of the patients. To compare the efficacy of spirinolactone with cyproterone compound vs. metformin on PCOS. This study was performed on 113 women, 20 to 30 years old, diagnosed to have PCOS, visited in Imam Hosein and Loghman outpatient clinics during three years. They came with complaints such as obesity hirsutism oligomenorrhea or amenorrhea Metformin is effective in improving obesity, hirsutism and oligomenorrhea of obese PCOS patient [regardless of their insulin resistance] [P< 0.005]. Metormin is more effective to reduce the body weight in obese women than those two [P< 0.05], on the other hand it has a limited effect on the hirsutism and oligomenorrhea of non-obese PCOS patients. Spirinolactone in conjunction with Dian is effective in improving the hirsutism, obesity and oligomenorrhea of the obese [regardless of their insulin resistance] [p< 0. 05] and non-obese patients [p< 0.005]. Metformin is more effective than Spirinolactone together with Dian on weight reduction in obese PCOS [p< 0.005], and Spirinolactone together with Dian is more effective on hirsutism and oligomenorrhea of non-obese patients than Metformin alone [p< 0.05]. Metoformin is effective to treat the obesity, hirsutism, and oligomenorrhea of the obese women and the combination of spirinolactone and cyproterone compound is more effective to treat hirsutism and oligomenorrhea in non-obese women with PCOS