Effect of rifampicin, isoniazid on acute and subacute inflammation in male Wistar rats: an experimental study.

Background: Tuberculosis (TB) is characterized by significant inflammation leading to complications like pulmonary fibrosis, constrictive pericarditis, etc. Drugs possessing anti-inflammatory activity can reduce the complications of infections occurring due to inflammation and fibrosis. To study the effect of rifampicin, isoniazid on acute and subacute models of inflammation in male Wistar rats. Methods: The in vivo anti-inflammatory activity of rifampicin, isoniazid was studied using acute (carrageenan paw edema) and sub-acute (cotton pellet granuloma and histopathologic examination of grass pith) models of inflammation. Results: Rifampicin and isoniazid used in the present study showed significant antiinflammatory activity in acute as well as subacute models of inflammation. Conclusion: Rifampicin and isoniazid when administered to treat TB can reduce complications of TB by virtue of its anti-inflammatory activity.

Promotion of cutaneous wound healing by famotidine in Wistar rats.

BACKGROUND & OBJECTIVE: Drugs like famotidine, omeprazole and sucralfate which have been reported to promote the healing of gastric ulcers, may have the same effect on cutaneous wounds. Due to paucity of information in this regard, the present study was planned to investigate the effect of these drugs on resutured incision, excision and dead space wounds in Wistar rats. METHODS:Resutured incision, excision and dead space wounds were inflicted under light ether anaesthesia aseptically. Control animals received vehicle and other groups received famotidine, omeprazole and sucralfate orally for a period of 10 days in the incision and dead space wounds, whereas in excision wounds till complete closure. On the 11th day after estimating breaking strength of the resutured incision wounds, animals were sacrificed and granulation tissue removed from dead space wounds to estimate the breaking strength and hydroxyproline content. Quantification of granulation tissue and histological studies were also carried out. Wound closure rate, epithelization time and scar features were studied in the excision wound models from the day of famotidine till complete closure of the wound. RESULTS: Only famotidine significantly promoted the healing process in all the three wound models studied. Histopathological studies revealed increased collagen content and granulation tissue in famotidine treated group compared to control. INTERPRETATION & CONCLUSION: In all the three wound models studied famotidine promoted wound healing whereas omeprazole and sucralfate did not do so. The pro healing effect of famotidine needs to be explored clinically.

Prevalence of Campylobacter pylori in non-ulcerative dyspepsia.

Endoscopic biopsies were taken from the gastric antral mucosa, in 150 cases of non-ulcerative dyspepsia at the Gastroscopic Clinic, Dist. Hospital, Belgaum. Spiral or curved bacilli, were demonstrated in specimens from 99 patients. The histologic demonstration of the organism by Warthin Starry stain (66%) was superior to Haematoxylin and Eosin (47.33%), Urease test (42%) and Gram's stain (35.33%). There was a strong association between C pyloridis in the gastric mucosa and histologically defined gastritis (95.55%).