Plasma concentration of vascular endothelial growth factor and its relation to diabetic vascular complications in [NIDDM] patients

This study was performed on 30 NIDDM patients with complications [diabetic nephropathy and retinopathy], 20 NIDDM patients without complications and 20 age and sex-matched healthy control subjects. NIDDM patients with complications showed a highly significant increase of plasma vascular endothelial growth factor [VEGF] than other two groups. NIDDM patients without complications had a higher VEGF than the control subjects. VEGF was correlated with fasting, 2-hour postprandial blood glucose levels, glycosylated, hemoglobin [HbA1c] and albumin excretion rate [AER], but it was not correlated to the duration of DM