RESUMEN
In our locality, hepatosplenic schistosomiasis [HSS]: is frequently encountered in association with diabetes mellitus. Diurnal variability of autonomic nervous system and hemostasis had been previously suggested in diabetic patients but not proved in HSS. The impact HSS on diurnal variability of heart rate, blood pressure, QT interval. QT. dispersion autonomic nervous system and hemostasis had not been previously studied in diabetic patients. Therefore, we studied ninety-five female patients: 30 patients with type 2 diabetes [diabetic group.], 30 patients with hepatosplenic schistosomtasis [HSS group], and 35 patients with combined diabetes mellitus and HSS [combined group] and thirty age-matched healthy women [control group]. The coexistence of diabetes mellitus and HSS affect many of the studied parameters. The combined group had more significant deterioration of deep breathing test: valsalva test and blood pressure response to sustained handgrip together with reduced plasma fibrinogen and euglobulin lysis time in comparison to the diabetic group. Altered diurnal variability of deep breathing test. Mean blood pressure and hemostasis were found in the combined group in comparison to the diabetic group. Loss of diurnal variability of Corrected QT interval [QTc] was also found in the three studied groups of patients in comparison to the control group. QTc and QT dispersion [QTD] were significant increased and correlated with autonomic function tests in the three studied groups of patients. it is concluded that, diurnal variability of autonomic nervous system, blood pressure and hemostasis should be considered during assessment of these variable Day-night difference in autonomic nervous system and arterial blood pressure together with hemostatic changes observed in the combined group in comparison to the diabetic group could be a possible explanation for the reduced occurrence and altered timing of cardiac events in the combined group. QTc and QTD are sensitive, noninvasive, simple predictors of cardiac autonomic dysfunction and could be used routinely to identify patients with autonomic dysfunction and increased cardiovascular risk