Sequential application of long pulsed dye/Nd-YAG lasers is a superior method for management of infantile hemangiomas

To evaluate the efficacy of sequential application of long Pulsed dye/Nd-YAG lasers in the management of skin and mucous membrane infantile hemangiomas. Management of infantile hemangiomas may be a challenge. Different laser systems have been reported to be of great help for such cases with variable results. In this study we present a unique sequential laser system which deliver pulsed dye laser PDL 595nm followed by Nd-YAG 1064nm to be superior than other reported techniques. Twenty five cases of infantile hemangiomas in the head and neck region were selected to he enrolled in this study. Assessment for progress was achieved clinically. We achieved excellent results in eighteen patients [72%] out of the treated 25 patients, with no recurrence after 6 months follow-up. Laser application from skin and mucous membrane sides [sandwich technique] decreased number of sessions. The sequential PDL followed by Nd-YAG laser can be considered as one of the superior methods for management of infantile hemangiomas specially in the head and neck region, due to its excellent cosmetic results with fewer number of treatment sessions

Maternal and fetal concentration of serum placental growth factor and their correlation to glycemic control and doppler study in diabetic and normal pregnancy

To determine whether maternal diabetes is associated with altered human placental growth factor [PIGF] level in serum of both mother and fetus and study he relation between PIGF and Doppler parameters, Prospective analytic comparative study. 30 normal pregnant female, 60 patients with gestational diabetes, 30 diabetic controlled and 30 diabetic uncontrolled. PIGF was measured in stored maternal serum samples taken in the 3[rd] trimester and cord sample of their babies after delivery by enzyme-linked immunosorbent assays [ELISA]. Diabetes during pregnancy was diagnosed with the 75-g oral glucose tolerance test and by applying world health organization criteria. Doppler velocimetry of umbilical vessels was evaluated for vascular impedance, in terms of pulsatility index and S/D ratio. Insignificant difference in serum maternal PIGF in both diabetic and non diabetic groups in the third trimester [p 0.139]. Cord serum PIGF was lower in diabetic controlled than uncontrolled group [p 0.023]. But there was significant negative correlation between maternal PIGF and cord serum PIGF in control [r -.537] and uncontrolled diabetic group [r -.384], p<0.05. Significant positive correlation between cord serum PIGF and S/D ratio was found [r .383], p<0.037. Significant negative correlation was found between PIGF in maternal serum and Doppler parameters in diabetic controlled group [r - 0.362], p value < 0.049 and in diabetic uncontrolled group [r = 0.500], p value < .005. FBS was positively correlated to cord serum PIGF in both controlled [r .603 and p value <0.001] and uncontrolled diabetic groups [r .934 and p value <0.001]. Maternal serum PIGF is similar in 3[rd] trimester in diabetic pregnancy and in control group. Serum cord PIGF was higher in uncontrolled than controlled diabetics. Significant negative correlation between maternal PIGF and cord serum PIGF in control and uncontrolled diabetic group. Rise in cord serum PIGF is related to chronic fetal hypoxia as evident by abnormal Doppler. Further studies are needed to confirm results

matigated role of selective Cox.2 inhibitors against the early effects of accumulated doses of gamma-irradiation in mice

Clinical and experimental studies of the early and late effects of radiation on cells have led to optimization of radiotherapy schedules and to more precise modes of radiation delivery, radiation induced-injury on normal tissue can present either during or after the completion of radiotherapy. Early effects of small accumulated doses of gamma-irradiation in mice were studied at the present work. Fifty four mice were classified as the following negative control group I, distilled water subgroup Iia, etodolac subgroup IIb, subgroup IIIa was irradiated by accumulated dose of 0.5 Gy, subgroup IIIb received etodolac half an our pre-0.5 Gy irradiation, subgroup IVa was irradiated y accumulated dose of 1Gy, subgroup Ivb received etodolac pre-1 Gy irradiation, suroup Va was irradicated by accumulated dose of 2 Gy and the last subgroup Vb received etodolac pre-2 Gy irradiation. Analysis of bone marrow and jejunal cell cycle kinetic was carried out using flowcytometery and histochemical studies. The results revealed hat there was significant dose-dependant alternation of cell cycle kinetic of bone marrow and jejunal samples in the form of increase in GI and CVGI and decrease in percent SPE, percent G2 and PI. Mitotic delay, reduction in DNA content and chromatin condensation underneath the nuclear membrane of the cells in both cypts and villi of the jejunal sections could be also observed. Etodolac adminisration to the mice half an hour pre-irradiation could offer a great radioprotective effect. Research opportunities may help future clinical application of selective cyclooxygenase-2 inhibitors as chemopreventive drugs