Therapeutic effect of L-carnosine on metabolic syndrome induced by hypercholesterolemia

The effect of hypercholesterolemia in rabbits was tested on serum protein fractions, lactate dehydrogenase isoenzymes, total protein and glucose levels. The work was extended to estimate certain hepatic enzymes; glucose-6-phosphatase [G-6-Pase], glycogen phosphorylase [GPH], alpha-hydroxybutyrate dehydrogenase [alpha-HBDH], lactate dehydrogenase [LDH] and glycogen content. The corrective action of carnosine and fluvastatin were also evaluated. Twenty five adult male Newzeland rabbits were selected for this study. The animals were divided into five groups. Group 1 served as normal healthy control, group 2; hypercholesterolemic animals [fed on standard rabbit's chow with 1% cholesterol for 12 weeks], group 3; high carnosine dose [50 mg/Kg b. wt.] treated animals, group 4; low carnosine dose [25 mg/Kgb. wt.] treated ones and group 5; fluvastatin [2mg/kg b.wt.] treated group. Treatment started at the last six weeks of cholesterol feeding. Hypercholesterolemic rabbits recorded drastic changes in all parameters under investigation. Carnosine and fluvastatin recorded an enhancement level in major parameters, where high carnosine dose recorded the most potent effect

Hepatoprotective effect of carnosine on liver biochemical parameters in chronic ethanol intoxicated Rat

The aim of the present study is to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters, enzymes, total proteins and glycogen in rats. These enzymes including Krebs cycle enzyme: succinate dehydrogenase [SDH]; glycolytic enzymes: lactate dehydrogenase [LDH] d its isoenzymes; glycogenolytic metabolic machineries: glycogen phosphorylase, G-6-Pase and glycoge" drolytic enzymes: acid phosphatase [AP] and alkaline phosphatase [ALP]; amino acid metabolic enzymes aspartate aminotransferase [AST] and alanine aminotransferase [ALT] and nucleic acid catabolic enzyme: 5-nucleotidase. The chronic ethanol-intoxicated rats showed a marked disturbance in all the parameters measured, indicating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effects of ethanol

Hepatoprotective effect of carnosine on liver biochemical parameters in chronic ethanol intoxicated rat

The aim of the present study was to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters; enzymes, total proteins and glycogen in rats. These enzymes including krebs cycle enzyme [succinate dehydrogenase [SDH]], glycolytic enzymes [lactate dehydrogenase [LDH]] and its isoenzymes [glycogenolytic], metabolic machineries [glycogen phosphorylase, G-6-Pase [G-6-P ase]] and glycogen [hydrolytic enzymes] acid phosphatase [AP] and alkaline phosphatase [ALT], amino acid metabolic enzymes [aspartate aminotransferase [AST] and alanine aminotransferase [ALT]] and nucleic acid catabolic enzyme [5'-nucleotidase]. The chronic ethanol-intoxicated rats showed a marked disturbance in all the measured parameters indicating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effect of ethanol by enhancement all of the measured parameters

Influence of capparis spinosa and acacia arabica on certain biochemical haemolymph parameters of Biomphalaria alexandrina

This work investigated the molluscicidal potency of dried Capparis spinosa and Acacia arabica leaves on some selected biochemical parameters of Biomphalaria alexandrina, in order to render them, physiologically, unsuitable for S. mansoni infection or at least disturb the lifecycle of the parasite within its respective snail host. The effect of the two plants on lactate dehydrogenase [LDH], 5'-nucleotidase, acid phosphatase [AP], aspartate and alanine aminotransferases [AST and ALT], alkaline phosphatase [ALP] and glucose content were studied. This work was extended to evaluate the effect of these two plants on protein profile as well as total protein [TP] content of snail's in hemolymph after 24 hours and 1 week of snails plants feeding. The study revealed that both plants induced a marked alteration in all measured parameters, where LC50 of C. spinosa after feeding at one week showed the most potent effect