Effect of different permeation enhancers on topical miconazole nitrate preparations

Miconazole nitrate was formulated into different topical preparations, including gels with different polymers, ointments as oleaginous, water-soluble bases and cream. In vitro skin permeation studies through rabbit skin to a receptor medium of [1:1] Methanol: phosphate buffer [pH6] For a period of 8 hour was studied. Different chemical enhancers as menthol, isopropyl myristate [IPM], oleic acid and ethanol, were incorporated into miconazole carbopol 934 P gel in different concentrations. They showed improved increase in Flux through rabbit skin. The best formula which showed significant flux was miconazole carbopol 934 p gel containing 10% menthol with the highest permeation of miconazole nitrate

Formulation and evaluation of cosmeceutical preparations loaded with triclosan beads

The present study aims at sustainment of the antibacterial action of Triclosan when applied to the scalp or the skin by Preparation of Triclosan-alginate beads in different concentration of sodium alginate beads, different ratios of drug-sodium alginate and with different concentrations of calcium chloride. The prepared beads were subjected to the drug entrapment efficiency. Incorporation of beads[4: 1 of drug: sodium alginate in 0.5% w/v] in cosmoceuticals preparations viz., cold cream, carbopol 934 gel, sodium carboxymethyl cellulose gel and Texapon N70 shampoo were subjected to determination of pH of different cosmoceuticals preparations before and after incorporation of beads, release studies of triclosan beads with and without drug beads, then Invitro release studies of cosmoceuticals preparation containing 1% in beads and 1% of free triclosan and 2% beads was determined using Franz-type diffusion cell in phosphate buffer of pH 5.8. Rheology of triclosan beads with and without free triclosan in pharmaceutical preparations were done in comparison with plain ones. The results reveled that, the highest rate and extent of Triclosan-l%in beads and 1%of free drug was given by CMC gel base which exhibited plastic thixotropic flow curve, the drug lowest release was exhibited by Texapon N70 shampoo .Pertaining to the release of Triclosan 2% beads, it was evident that the highest release was from CMC gel base which exhibited plastic thixotropic flow curve, while the least release rate was from Texapon N70 shampoo exhibited plastic thixotropic flow curve with smaller extent