RESUMEN
Abstract This study investigates whether trust in government policies has a mediation effect between the students' perception of COVID-19 health risk and their life satisfaction. In order to test the mediation effect, this study utilizes data collected from undergraduate students at Tecnológico de Monterrey in Mexico by means of online survey. The survey yielded 95 usable data out of 97. The valid results were tested via generalized linear model (GLM) Mediation approach for the mediation. Empirical findings of Delta method affirm the mediation (estimate = 0.4445, β = 0.474, z = 3.699, p < .001) role of trust in government as a mediator between students' perception of COVID-19 health risk and their life satisfaction. In other words, Mexican undergraduate students are of the view that trusting government plays a crucial role as a mediator between their perception of coronavirus health risk and life satisfaction. These findings may guide the governments' policy making efforts and motivate them to support their initiatives with trust-building efforts.
Resumo Este estudo investiga se a confiança nas políticas governamentais tem um efeito de mediação na percepção dos estudantes sobre o risco de saúde da COVID-19 e a satisfação de vida. A fim de testar o efeito de mediação, o estudo utiliza dados recolhidos de estudantes universitários do Tecnológico de Monterrey, no México. O inquérito produziu 95 dados utilizáveis de um total de 97. Os resultados válidos foram testados por meio da abordagem de mediação do modelo linear generalizado (GLM). Os resultados empíricos do método Delta afirmam (estimativa = 0,4445, β = 0,474, z = 3,699, p < .001) o papel de confiança no governo como mediador entre a percepção dos estudantes sobre o risco de saúde da COVID-19 e sua satisfação de vida. Em outras palavras, para os estudantes de graduação mexicanos a confiança no governo desempenha papel crucial como mediador entre suas percepções sobre o risco de saúde do coronavírus e a satisfação de vida. As conclusões do estudo podem orientar os esforços dos governos na elaboração de políticas e motivá-los a apoiar iniciativas de criação de confiança.
RESUMEN
Abstract The latest statistics show that COVID-19 is still very active, and cases are on the rise across various countries and regions. On the other hand, statistics from Pakistan show a declining trend, especially during the first wave of the COVID-19 pandemic. To understand this declining trend and answering our established question, "What are the reasons behind the decline of the COVID-19 cases in Pakistan - public healthcare facilities or government smart lockdown policy?" narrative literature-based evidence collected from government official websites, reports and also Google Scholar. Our findings suggest that the government's innovative smart lockdown strategy and its execution at the right time with the consensus of all stakeholders accompanied with the observing of COVID-19 standard operation procedures resulted in controlling the pandemic. Effective smart lockdown policy allows the government to identify shortcomings of and improve the capabilities of healthcare for the continuation of balanced socio-economic activities to avoid future spread-out of the pandemic in the time of crisis under national and World Health Organization guidelines.
Resumo As últimas estatísticas mostram que a COVID-19 ainda está muito ativa, e os casos estão aumentaando em vários países e regiões. Por outro lado, as estatísticas do Paquistão mostram uma tendência decrescente, em especial durante a primeira onda da pandemia de COVID-19. Para compreender esta tendência decrescente e responder à nossa pergunta estabelecida, "Quais são as razões por detrás do declínio do caso COVID-19 no Paquistão - instalações públicas de saúde ou política de encerramento inteligente do governo?" - foi compilada evidências narrativas baseadas em literatura recolhida de websites oficiais do governo, relatórios e também no Google Scholar. As nossas conclusões sugerem que a estratégia inovadora de encerramento inteligente do governo e a sua execução no momento certo, com o consenso de todos os interessados acompanhados pela observação dos procedimentos de operação padrão da COVID-19, resultou no controle da pandemia. Uma política eficaz de encerramento inteligente permite ao governo identificar deficiências e melhorar as capacidades dos cuidados de saúde para a continuidade de atividades socioeconômicas equilibradas, a fim de evitar a propagação futura da pandemia em tempo de crise, sob as diretrizes nacionais e da Organização Mundial de Saúde.
RESUMEN
Obesity is a chronic pathological condition characterized by an increased body fat accumulation to the extent that it may have an adverse effect on the health. Depression is the most common co-morbidity of obesity, which may cause the Binge Eating Disorder (BED), leading to morbid obesity. In the present project a dispersible 60mg Orlistat (ORST) and β-cyclodextrin (β-CD), (1:2M) complexed core tablet is press coated with the taste masked 75mg Venlafaxine Hcl. (VLFXN) microparticles, prepared with Eudragit EPO (1:3), by emulsification solvent evaporation method, to obtain the chewable tablet-in-tablet dosage form. A Reverse phase (RP)-HPLC method was developed for the simultaneous estimation of ORST and VLFXN in the formulation. The optimized formulation was palatable and there was no drug excipients interaction which was confirmed by IR Spectrum. Press coated, tablet-in-tablets were evaluated for physicochemical properties. All the values obtained were within the standard limits. And in the in-vitro dissolution study the release of both drugs, ORST and VLFXN at the end of 15mins was found to be 86% and 92% respectively. Hence, the developed chewable tablet-in-tablet formulation of ORST and VLFXN can be a viable drug delivery system for treating patients with obesity and BED.
RESUMEN
The ribosomal phosphoprotein P0 of the human malarial parasite Plasmodium falciparum (PfP0) has been identified as a protective surface protein. In Drosophila, P0 protein functions in the nucleus. The ribosomal function of P0 is mediated at the stalk of the large ribosomal subunit at the GTPase centre, where the elongation factor eEF2 binds. The multiple roles of the P0 protein presumably occur through interactions with other proteins. To identify such interacting protein domains, a yeast two-hybrid screen was carried out. Out of a set of sixty clones isolated, twelve clones that interacted strongly with both PfP0 and the Saccharomyces cerevisiae P0 (ScP0) protein were analysed. These belonged to three broad classes: namely (i) ribosomal proteins; (ii) proteins involved in nucleotide binding; and (iii) hypothetical integral membrane proteins. One of the strongest interactors (clone 67B) mapped to the gene YFL034W which codes for a hypothetical integral membrane protein, and is conserved amongst several eukaryotic organisms. The insert of clone 67B was expressed as a recombinant protein, and immunoprecipitaion (IP) reaction with anti-P0 antibodies pulled down this protein along with PfP0 as well as ScP0 protein. Using deletion constructions, the domain of ScP0, which interacted with clone 67B, was mapped to 60-148 amino acids. It is envisaged that the surface localization of P0 protein may be mediated through interactions with putative YFL034W-like proteins in P. falciparum.