Assessment of factors influencing vaccine hesitancy for coronavirus disease-19 vaccines among the population of National Capital Region, India

Background: Acceptance of vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among general population is the most important step in combating coronavirus disease 2019 (COVID-19). In India, there is a lack of studies that recorded and assess the factors affecting the motivation of general public toward vaccination against COVID-19. Aim and Objective: The aim of this study was to assess the acceptance and/or hesitancy about the COVID-19 vaccine and the association of various demographic indicators in the population of the National Capital Region, India. Material and Methods: Cross-sectional study was conducted between March 15, 2021 and April 15, 2021, using pre-validated questionnaire containing 20 items. Data obtained was analyzed using the Microsoft excel platform using descriptive statistics. Results: Majority of 438 (45.5%) participants in our study agreed that the COVID-19 vaccine is important for their health. In this study, 323 participants said “yes,” 179 said “No,” 201 (20.9%) said “May be” regarding the key question about opinion of getting COVID-19 vaccination. About 395 (40.9%) agreed that they have concerns about the serious adverse effects of COVID-19 vaccines. A considerable portion of 316 (32.89%) of participants also thought newer vaccines carry more risks. Substantial population 286 (29.6%) also thinks the current COVID-19 vaccines are not useful against all existing variants of the CoV-2 virus. Conclusion: Vaccine hesitancy in this study reflects the concerns about the serious adverse effects, exposure to unreliable information, and probes towards vaccine infectiveness. Dissemination of the evidence-based information about the necessity, effectiveness, and safety of COVID-19 vaccines is required to enable the general population to make the right informed decision.

Aneurysm of sinus of Valsalva dissecting into interventricular septum with left ventricular communication.

Septal dissection with left ventricular communication is a rare complication of aneurysm of sinus of Valsalva. This report describes a case of aneurysm of sinus of Valsalva with septal dissection, almost in its entirety with left ventricular communication--which is a very rare occurrence.

Neuroleptic malignant syndrome: an experience of four cases.

We report four cases of neuroleptic malignant syndrome occurring after administration of a typical antipsychotic haloperidol and a newer atypical antipsychotic clozapine. The management of these patients is discussed.

Pattern of childhood trauma. Indian perspective.

Although infectious diseases are still the chief cause of death in children in a developing country like ours, but a definite increase in incident and related mortality due to trauma has been noted in the last decade. The problems relating to pediatric trauma are peculiar to our setup and differ considerably to the severe multiple organ trauma met with in the high velocity vehicular accidents, seen in developed Western countries. The present study identifies patterns of childhood trauma from our region. It comprises 2100 patients admitted over a 3 years period to Pediatric Surgical Unit. Cranial injuries were the most commonly encountered injuries followed by the abdominal and skeletal injuries. Fall from the house roofs is the commonest mode of injury, although road traffic accidents are also recognized to be on the increase. The overall mortality was 7.7%; its chief determinant being the presence of severe head injury. A few important epidemiological factors involved were identified.

Knowledge amongst adolescent girls about nutritive value of foods and diet during diseases, pregnancy and lactation.

Knowledge about nutritive value of food, diet during diseases and antenatal and postnatal period was assessed amongst 152 adolescent school girls. A total of 23.69 and 55.93% students had incorrect knowledge that pulses and non-vegetarian foods should be avoided during later half of the pregnancy. A total of 63.82, 66.45 and 71.72% of subjects had incorrect knowledge that almonds have more nutritive value than groundnuts, fruits are rich sources of calories and desi ghee has more nutritive value than vanaspathi, respectively. Majority (90.78%) had correct knowledge that obesity is caused due to excess intake of calories than required by an individual and low iron content and poor availability of iron from food is a major cause of anemia in mothers and children.

Assessment of knowledge and skills about growth monitoring amongst child development project officers.

Knowledge and skills about growth monitoring (GM) amongst Child Development Project Officers (CDPOs) were assessed by interview technique. Majority (94%) of subjects had correct knowledge that GM helps in early detection of growth retardation while about 83% felt that a flattened growth curve indicates no weight gain. The percentages of CDPOs who were able to interpret and read correctly about what ascending descending and flattened growth curves indicate were 83, 71 and 50% respectively. There is thus a need of in-service training of CDPOs in GM activities.

Assessment of knowledge and attitudes in human nutrition among nurses of Delhi.

The present study revealed that the majority of nurses had adequate knowledge about dietary practices during the antenatal and post-natal period. However, their knowledge about nutritive value of foods and nutrition advice during disease conditions was inadequate. It is recommended that to make the training more meaningful, the identification of the incorrect dietary beliefs of trainees should be done at the beginning of the training course. Each incorrect belief should be explained in detail for better comprehension of the correct knowledge in nutrition.

Knowledge and attitude amongst well-to-do adolescent school girls towards breast feeding.

A study was conducted to determine the knowledge and attitude about breastfeeding amongst adolescent school girls (n = 74) studying in an urban public school in Delhi. A pretested semi-structured questionnaire was administered. The majority of respondents had correct knowledge about the age of initiation of breast feeding (76%), introduction of semi-solid foods (61%), feeding of colostrum (58%) and superiority of breast milk over commercial preparations of milk (81%). Most believed wrongly that consumption of dry fruits (89%) and high intake of milk and pure ghee (78%) would increase breast milk secretion. The percentages of girls wrongly believing that breast feeding should be discontinued if mother was suffering from tuberculosis, malaria and diarrhea were 96, 85 and 81 respectively. There is need for including adolescent girls in continuing education activities about maternal and child health.

Knowledge and attitude towards breast feeding among adolescent girls.

Majority of the urban adolescent girl students (n = 76) from middle socioeconomic group correctly reported that breast milk is the best food for infants (95%), and it has protective antibodies (98%). However, most of them (92%) had incorrect knowledge about the role of diet in breast milk secretion and continuation of breastfeeding while mother is suffering from tuberculosis (92%), malaria (84%).

Knowledge of nutritive values of foods and diet during diseases amongst nursing students.

Knowledge about nutritive value of foods and diet during diseases was assessed amongst forty nine nursing students at the beginning of their training course in Human Nutrition. Majority of the students had correct knowledge about dietary advice during antenatal and postnatal period. The knowledge of nutritive values of foods and diet during disease conditions was inadequate.

Knowledge and attitude among child development project officers towards breast feeding.

A study was conducted to determine the knowledge and attitude about breast feeding (BF) amongst child development project officers (CDPOs) working in Integrated Child Development Services Scheme. A semi structured pretested questionnaire was administered. It was found that majority of respondent had correct knowledge about feeding of colostrum, age of initiation of breast feeding and introduction of semi-solid foods. Majority of CDPOs had the knowledge that consumption of dry fruits, milk and desi ghee would increase that breast milk secretion. The percentage of subjects who were aware that BF should be discontinued if mother is suffering from illness like breast cancer (48%) tuberculosis (57%), malaria (67%) and Diarrhoea (84%). There is need of continuing education of CDPOs for updating their knowledge.

Knowledge attitude towards breast-feeding amongst auxiliary nurse midwives in rural Delhi.

A study was undertaken to determine the knowledge and attitude about breastfeeding amongst auxiliary nurse midwives (ANMs) working in rural Delhi. It was found that all respondents had correct knowledge about age of initiating breastfeeding, feeding of colostrum and superiority of breast milk over commercial milk preparations. About 76% responded that top milk given after 4 months of age should be diluted. A majority of workers mentioned that consumption of dry fruits, high quantity of milk and ghee increases the quantity of breast milk secretion. The percentage of ANMs who thought that breast-feeding should be discontinued if mother is suffering from an illness were: breast cancer (68%), tuberculosis (56%), malaria (50%) and diarrhea (36%). There is need for continuing education of peripheral health functionaries for updating their knowledge.

Lipids changes in alcoholic & non-alcoholic cirrhotics.

Fasting plasma samples from 29 patients of cirrhosis were analysed for cholesterol and triglycerides and their lipo-protein fractions. The patients included 11 alcoholic cirrhotics consuming over 130 g/day of absolute ethanol and 18 non-alcoholic cirrhotics. The difference in lipid values between the two patient groups was not significant except that VLDL cholesterol was raised in alcoholic cirrhotics (P less than 0.05). However, in comparison to normal healthy controls, the values were significantly altered. The dietary intake, in the two groups showed no difference, except that non-alcoholic cirrhotics consumed more animal proteins. Low intake of exogenous fat and reduced synthesis of endogenous cholesterol in cirrhotic patients seemed to influence the total lipid values.