RESUMEN
OBJECTIVE To identify and evaluate the risk factors in the operation process of the vaccine supply chain ，clarify the importance of each process risk in the overall risk of the vaccine supply chain ，and provide reference for stakeholders in the vaccine supply chain to formulate risk management and control strategies. METHODS In the supply chain operation reference model，the risk factors existing in the operation of vaccine supply chain were identified ，and the vaccine supply chain risk evaluation index system was constructed. The best-worst method and entropy weight method were used to determine the subjective and objective weight of the index ，and the Lagrange multiplier method was used to solve the optimal combination weight value of the index. RESULTS & CONCLUSIONS A vaccine supply chain risk evaluation index system with 18 indexes was established. Only 67％ of the indexes reflected 85％ of the vaccine supply chain risk information. The construction of the system was reasonable. The results showed that the risk weight of production process was 0.607，which accounts for the highest weight in the overall risk of vaccine supply chain ，followed by procurement （0.234），distribution（0.102），planning（0.053）and return （0.004） process risk . When managing and controlling risks ，enterprises should attach great importance to the risk factors in vaccine production；at the same time ，enterprises should also focus on other risks such as unqualified materials for products ，mixed use of materials and so on.
RESUMEN
Objective To present study was to investigate the effects of insulin-like growth factor binding protein 7 (IGFBP7)on the proliferation of human hepatocellular carcinoma HepG2 cells.Methods Human hepatocellular carcinoma HepG2 cells was cultured,and plasmid pIRES2-ZsGreen1-IGFBP7 or empty plasmid was transfected into HepG2 cells and the cell transfection efficiency was examined by fluores-cence microscopy;MTT was performed to evaluate the effect of IGFBP7 on proliferation and apoptosis of HepG2 cells in 48 hours after transfection.Results IGFBP7 transfected group decreased cell proliferation noticeably.Conclusions Overexpression of IGFBP7 can down-regulte the proliferation of human hepatocel-lular carcinoma HepG2 cells.