RESUMEN
Statement of the Problem: Oral mucositis [OM] is a common side effect of anticancer drugs and needs significant attention for its prevention
Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster
Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections [days 0, 5 and 10] and the abrasion of the cheek pouch [days 3 and 4]. On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment [control] for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments
Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups [p= 0.000]. Significant decreases in white blood cell, hemoglobin, hematocrit, and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups [p< 0.05]
Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties
RESUMEN
Statement of the Problem: Matrix metalloproteinases [MMPs] have been implicated in the pathogenesis of certain diseases and cancers via tissue destruction and can be secreted into the blood stream. MMP9 expression in the salivary gland tissue was evaluated but their serum level in the salivary gland tumors was not studied
Purpose: The aim of our study was to determine the concentration of serum MMP-9 in healthy participants and in patients with salivary gland tumor
Materials and Method: Using an ELISA kit, the circulating levels of MMP-9 in sera from 58 patients with salivary gland tumor [31 pleomorphic adenoma, 17 adenoid cystic carcinoma and 10 mucoepidermoid carcinoma] and 30 healthy controls was assessed
Results: The serum MMP9 level in patients with salivary gland tumors [380.0 +/- 301.3 pg/ml] also patients with benign tumors [354.3 +/- 218.7 pg/ml] [354.3 +/- 218.7 pg/ml] were significantly lower than that in the healthy group [727.4 +/- 624.6 pg/ml] [Respectively p= 0.02 and p= 0.01]. Mean serum MMP9 concentration in malignant tumors was [402.3 +/- 441.8pg/ml] higher than benign tumors [354.3 +/- 218.7 pg/ml] but the difference was not significant [p= 0.9]
Conclusion: Our results showed that serum level of MMP9 decreased in patients with salivary gland tumors which suggest that MMP9 may not have a potential role in development and pathogenesis of salivary gland tumor
RESUMEN
Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor [VEGF] is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal individuals and consider its clinical significance. In this case-control study, 36 serum samples from patients diagnosed with oral lichen planus admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences [14 men, 22 women, mean [ +/- SD] age: 38.8 [ +/- 6.07] years] and 23 serum samples from healthy individuals [9 men, 14 women, mean [ +/- SD] age: 38.7 [ +/- 4.9] years] were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis. The serum VEGF level was significantly higher in patients with oral lichen planus compared with the healthy controls [112.97 [ +/- 63.2] vs. 66.21 [ +/- 56.2] ngr/ml, P < 0.001]. A similar difference was also observed between the two types of oral lichen planus, being more pronounced in the erosive form [P < 0.001]. Serum VEGF can be used as a useful and suitable marker to scrutinize the disease activity