RESUMEN
Background and Aim: Probiotic products may have positive effects in the non-alcoholic fatty liver disease [NAFLD]. The aim of this study was to investigate the effects of consumption of probiotic yogurt on some metabolic factors in the patients with nonalcoholic fatty liver disease [NAFLD]
Material and Methods: This double-blind, randomized, controlled clinical trial included 72 patients between 23 to 63 years of age with NAFLD [33 males and 39 females]. The intervention group [n = 36] consumed 300 g/d of pro-biotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and the control group [n = 36] consumed 300 g/d of conventionalyogurt for 8 weeks. Using SPSS software version 16, data analysis was performed by chi-square test, independent sample t-test, analysis of covariance, and paired sample t-test
Results: Fasting blood samples, anthropometric measurements, and dietary records [24 h/day for 3 days] were collected at baseline at the end of the trial. Probiotic yogurt consumption resulted in 4.67%, 5.42%, 4.1%, and 6.92% reductions of serum levels of alanine aminotransferase, aspartate aminotransferase [P<0.02], total cholesterol [P<0.001], and low-density lipoprotein cholesterol [P<0.001], in the intervention group, compared to the control group. Both groups showed no significant changes in the levels of serum glucose, triglyceride, or high-density lipoprotein cholesterol [P>0.05]
Conclusion: Probiotic yogurt consumption improved hepatic enzymes, serum total cholesterol, and low-density lipoprotein cholesterol levels in the subjects. Therefore, it might be useful in the management of NAFLD risk factors
RESUMEN
In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant status in beta-thalassemic major patients. This double blind randomized clinical trial was carried out on 120 beta thalassemic patients older than 18 years. Patients were randomly categorized in four groups. Zinc [50mg/day] and vitamin E [400mg/day] supplements were administered for former and latter group, respectively. In the third group both supplements were administered in similar doses. The fourth [control] group received no supplement. The effect of supplementations on serum zinc and vitamin E, superoxide dismutase [SOD], glutathione peroxidase [GPX], total antioxidant capacity [TAC] and body mass index [BMI] were measured at the beginning and the end of the study. Serum zinc levels in group 1 and 3 were significantly increased [P<0.007 and P<0.005, respectively]. Serum vitamin E levels in group 2 and 3 were also increased significantly [P<0.001]. Mean GPX activity in group1, 2 and 3 decreased significantly [P<0.015, P<0.032 and P<0.029, respectively]. Mean SOD activity and TAC did not show significant change after supplementation. BMI had significant increase in all treated groups [P<0.001]. Our results suggest that beta thalassemic patients have enhanced oxidative stress and administration of selective antioxidants may preclude oxidative damage