Evaluation of the appropriate size of follicles on success rate in patient undergoing controlled ovarian stimulation and intrauterine insemination cycles

Objectives: Intra-Uterine Insemination [IUI] is one of the methods for infertility treatments. The size of the follicles and endometrial thickness are two important factors in pregnancy rate of patients undergoing controlled ovarian stimulation and intrauterine insemination cycles [COH-IUI]. The aim of this study was to investigate the success rate of IUI and follicular size and other associated factors in infertile couples

Materials and Methods: The study group was the patients who were undergoing COH-IUI. BMI of all women recorded and ovulation induction was propelled and when there was appropriate endometrial thickness and at least one dominant follicle in trans-vaginal ultrasonography. 36 hours after HCG injection, IUI was performed. Then pregnancy rate between patients who had follicle size fewer than 20 mm and higher than 20 mm was assumed

Results: 159 cases of IUI were performed and pregnancy happened in 22[14.1 %]. In non-pregnant group [134 cases], 78 cases had under 20 mm follicles and 47 cases had higher than 20 mm follicles. In pregnant group [22 cases] 10 cases had fewer than 20 mm follicles and 12 cases had higher than 20 mm follicles in the time of HCG injection. Endometrial thickness was 8.01+/-1.42 mm in patients with follicles more than 20 mm

Conclusion: The success rate in controlled ovarian stimulation and intrauterine insemination cycles closely related to obtaining of optimal size of follicles and endometrial thickness

Does progesterone suppository to luteal phase support have any effect on pregnancy rates in the intrauterine insemination cycles?

Objectives: Rate of infertility in overall is around 15-10%. Intra-Uterine Insemination [IUI] is one procedure for infertility treatment. Luteal phase support defect is a main factor in fail of pregnancy. Goal of this study was to evaluate the effect of luteal phase support with progesterone suppository in patients who undergoing IUI cycles

Materials and Methods: 100 infertile couples who were undergoing IUI treatment included in this study. Ovulation induction was done for all patients. When IUI was done, patients were distributed into two groups. The study group [n=50] received progesterone suppository and control group [n=50] doesn't received any medicine. Then biochemical pregnancy rate, clinical pregnancy rate and abortion rate compared between two study groups

Results: There were no differences in basic characteristics between two groups. Biochemical and clinical pregnancy were parallel in the study and control groups. There were no statistically significant increases in abortion rate between the study groups [P=0.49]

Conclusion: Luteal phase support by progesterone suppository does not improve the pregnancy rate of stimulated IUI cycles