Comparison of two different injectable contraceptive methods: depo-medroxy progesterone acetate [DMPA] and cyclofem

To compare side effects between users of two kinds of injectable contraceptives [Depo-medroxy progesterone acetate and Cyclofem]. This cross-sectional descriptive study included 250 women, aged 18-40 years, using Depo-medroxy progesterone acetate [DMPA] or Cyclofem. The volunteers were examined six months after using contraceptive, and they were asked about following symptoms: weight changes, irregular bleeding, dysparounia, vaginal dryness, headache, breast pain, bone pain, and discontinuation reason. The data were analyzed by statistical methods. The important side effects of DMPA were: irregular bleeding [93.60%], weight gain [48%], bone pain [24%] and vaginal dryness [10.40%], while the side effects in the Cyclofem group were: irregular bleeding [65.60%], headache [14.4%] and breast sensitivity [20%]. Bleeding pattern changes were the most important problem leading to discontinuation of both contraceptive methods in our participants. The results of the study showed that the most important problem in both groups was change in bleeding pattern. Proper consulting by a trained expert reduces the high amount of discontinuation and their failure rates

Abdominal compartment syndrome due to OHSS

Abdominal compartment syndrome is a dangerous clinical situation, usually following abdominal injuries and operations. It is seldom observed in patients with gynecologic and obstetric problems. Abdominal compartment syndrome may be consequence ovarian hyperstimulation syndrome. A 28-year-old woman presented as a sever ovarian hyperstimulation.The increased IAP indicated that OHSS may be considered a compartment syndrome. Abdominal compartment syndrome needs laparotomy or paracentesis for reduction of pressure

Cytogenetic analysis of 358 bone marrow samples of suspected Acute Lymphoblastic Leukemia patients

Acute Lymphoblastic leukemia [ALL] is characterized by the accumulation of malignant, immature lymphoid cells in the bone marrow and in most cases also in peripheral blood. The disease is much more common in children than in older age group, with the incidence peaking around 3-5 years of age. Initial cytogenetic studies showed chromosomal aberrations in approximately half of all patients with ALL. Later studies and the combined use of FISH and molecular techniques have shown that the rates of detected chromosomal aberrations are 70% to 80% in these patients. The rates of detection in ALL have never been reported in Iran and we are reporting our cytogenetic findings in 358 ALL cases. We evaluated the karyotypes of 358 [21%] bone marrow samples sent to our center for cytogenetic study from patients with probable clinical diagnosis of ALL. All samples were submitted to a cell count and cultures were set up accordingly using standard protocols. Chromosomal aberrations were detected in 155 [49%] out of 314 successful cultures and the remaining 159 [51%] showed normal karyotypes. Hyperdiploidy in two forms of moderate and massive was the most common chromosomal aberration, found in 63 [40%] cases, followed by 14q abnormality in 13 [8%] and deletion of long arm of chromosome 6 in 9 [6%] of the cases. The ratios of detected numerical and structural chromosomal changes are close to and comparable with various series studies based on banding cytogenetic techniques alone. We believe that the implementation of complementary FISH and molecular cytogenetic techniques, and closer communication with the referring physicians are extremely instrumental in improving the effectiveness of cytogenetics study