RESUMEN
Objective: Diabetes is a common metabolic disorder that a one of the important factors in the etiology is considered to oxidative damage. The present study intends to study the effect of swimming training with Arbutin on total oxidant status [TOS] and total antioxidant status [TAS] in kidney tissue of Alloxan-induced diabetic rats
Methods: We randomly divided 42 male Wistar rats that had an average weight of 195 g to 220 g into 6 groups [7 rats per group] - control, diabetic, arbutin, diabetic-arbutin, diabetic-swimming training, and diabetic-combinatorial. Swimming training protocol consisted of 5 days/week for 6 weeks at 5-36 min/day. Diabetes was induced with alloxan [90 mg/kg, intraperitoneal [ip]] in the rats. Arbutin [50 mg/kg, subcutaneous] was administered for 5 days/week. The rats were killed 48 hours after the last treatments and kidney TOS and TAS levels were evaluated. One-way analysis of variance was used for data analysis
Results: After six weeks of supplementation with arbutin, swimming training and the combination of swimming training and arbutin, we observed a significant decrease in TOS [P<0.05] and elevated TAS [P<0.05] levels in the alloxan-induced diabetic rats
Conclusion: The combined effect of swimming training and arbutin supplementation can play a major role against renal oxidative stress by modulating total oxidant and antioxidant status in alloxan-induced diabetic rats