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Japanese Journal of Complementary and Alternative Medicine ; : 19-23, 2023.
Artículo en Japonés | WPRIM | ID: wpr-1007152

RESUMEN

The anti-inflammatory and anti-oxidant effect of equine placental extract (ePE) on epidermal keratinocytes was examined. ePE reduced mRNA levels of TNF-α (Tumor Necrosis Factor-α) and IL-6 (Interleukin-6) among the inflammatory cytokines released by epidermal keratinocytes after ultraviolet light (UVB: 290-320 nm) exposure. ePE also activated Nrf2, a transcription factor known to be activated by oxidative stress to promote the expression of antioxidant enzymes and suppress inflammation, and it increased the mRNA level of the antioxidant enzyme HO-1 (Heme Oxygenase-1). These results suggest that ePE suppresses UV-induced inflammation of epidermal keratinocytes via activation of Nrf2.

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