Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents of Ligusticum chuanxiong.</p><p><b>METHOD</b>The constituents were separated and purified by column chromatography with silica gel and ODS, and identified by NMR, MS spectral data.</p><p><b>RESULT</b>Eight compounds were isolated and identified as Ligustilide(I), 4,5-dihydro-3-butylphthalide(II), Z, Z'-6,6',7,3 alpha-diligustili-de(III), Z-6,8',7,3'-diligustilide(IV), Z'-3,8-dihydro-6,6'7,3' alpha-diligustilide(V), 4-hydroxy-3-butylphthalide(VI), ferulic acid(VII) and Xiongterpene(VIII).</p><p><b>CONCLUSION</b>Compound VIII is a new compound.</p>

Efficacy of ESP Monitoring during Thoraco-Abdominal Aortic Replacement for Prevention of Intraoperative Spinal Ischemia / 日本心臓血管外科学会雑誌

We evaluated the efficacy of evoked spinal potential (ESP) monitoring during thoracoabdominal aortic replacement to prevent intra-operative spinal ischemia. Nine patients underwent intraoperative ESP monitoring. The ESP was unchanged in 5 patients and decreased in 4 patients. However, ESP recovered in 2 of them by the following techniques: (1) perfusion of intercostal arteries, (2) elevation of distal bypass perfusion pressure, (3) slight hypothermia. Postoperative paraplegia occurred only 1 patient of the 2 whose ESP was not restored. The sensitivity and specificity of the efficacy of ESP monitoring were 100% and 87.5%, respectively. We concluded that ESP is the most useful monitoring for prevention of operative spinal ischemia during thoracoabdominal aortic replacement.