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Gut and Liver ; : 421-427, 2014.
Artículo en Inglés | WPRIM | ID: wpr-175278

RESUMEN

BACKGROUND/AIMS: The present study aimed to clarify whether virological response within 2 weeks after therapy initiation can predict a null response to pegylated interferon alpha-2b plus ribavirin therapy in patients with high viral load genotype 1b hepatitis C. METHODS: The participants consisted of 72 patients with high viral load genotype 1b. The dynamics of viral load within 2 weeks were measured. RESULTS: Significant differences between null responders and nonnull responders were noted for interleukin (IL)-28B genotype, amino acid 70 substitution, alpha-fetoprotein, low-density lipoprotein cholesterol, hyaluronic acid, and viral response. The area under the curve (AUC) for the receiver operating characteristic curve of the hepatitis C virus (HCV) RNA level decline at 2 weeks (AUC=0.993) was the highest among the factors predicting the null response. When the cutoff value for the HCV RNA level decline at 2 weeks was set at 0.80 log, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting a null response were 82%, 96%, 82%, 96%, and 94%, respectively. In comparison, values for the non-TT and mutant type of amino acid 70 substitution were similar to those for HCV RNA level decline at 2 weeks. CONCLUSIONS: Virological response at 2 weeks or the combination of IL-28B and amino acid 70 substitution are accurate predictors of a null response.


Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Adulto Joven , Administración Oral , Antivirales/administración & dosificación , Área Bajo la Curva , Quimioterapia Combinada , Genotipo , Hepatitis C Crónica/tratamiento farmacológico , Inyecciones Subcutáneas , Interferón-alfa/administración & dosificación , Cumplimiento de la Medicación , Polietilenglicoles/administración & dosificación , Estudios Prospectivos , ARN Viral/metabolismo , Proteínas Recombinantes/administración & dosificación , Ribavirina/administración & dosificación , Resultado del Tratamiento , Carga Viral
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